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Flolan (Prostacyclin, Epoprostenol)

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer

Flolan (Epoprostenol) by GlaxoSmithKline is given continuously through an indwelling catheter.

Survival in Systemic Sclerosis with Pulmonary Arterial Hypertension Has Not Improved in the Modern Era. Despite an improvement in clinical status, unlike patients with pulmonary arterial hypertension, the mortality in systemic sclerosis has not improved since the introduction of epoprostenol. CHEST Journal, June 6 2013. (Also see Pulmonary Hypertension Prognosis)

This study is ongoing, but not recruiting, as of 10-22-12:

Study of a New Thermo Stable Formulation of Epoprostenol Sodium to Treat Pulmonary Arterial Hypertension (PAH). This multicentre, open label, single-arm study in approximately 20 adult patients will evaluate the impact on lifestyle of a new thermo stable formulation of epoprostenol sodium in subjects with Pulmonary Arterial Hypertension (PAH). ClinicalTrials.gov.

A Randomized Controlled Trial of Epoprostenol Therapy for Severe Congestive Heart Failure: The Flolan International Randomized Survival Trial (FIRST). This study was for heart-failure patients (not PH patients), and the results were so bad the study was ended early, because the patients were dying off at an increased pace. Medscape.

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