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Inhaled Prostacyclin (Iloprost, Ventavist)

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer

Possible anti-metastatic effect of Iloprost in a patient with systemic sclerosis (SSc) with lung cancer: a case study. Herein, we report iloprost treatment of a 60-year-old-woman with SSc, who lately developed pulmonary hypertension as a complication of her disease and lung adenocarcinoma as a co-incidence simultaneously. Yavuz Pehlivan, Reheumatology International, 30 March 2011 (Also see Cancer)

Severe vascular complications in patients affected by systemic sclerosis cyclically treated with iloprost. With the limits of an observational study and in the absence of a control group, our experience suggests that prolonged cyclic iloprost therapy may limit the incidence/progression of severe digital and visceral SSc-vasculopathy. Paola Caramaschi, Rheumatology International, 30 March 2011 (Also see Vascular Involvement)

Intravenous epoprostenol (iv PGI) versus high dose inhaled iloprost for long-term treatment of pulmonary hypertension. In this patient population with severe pulmonary hypertension of different etiologies, event free follow up on treatment with iv PGI is significantly longer compared to high dose inhaled Iloprost. Reichenberger F. (PubMed) Pulm Pharmacol Ther, 2010 Jun 25. (Also see Flolan)

Drug may prevent lung cancer, study finds. The drug, called Iloprost, is approved in inhaled forms to treat pulmonary hypertension, when blood pools near the lungs, a connective tissue disease called scleroderma and a nerve condition called Raynaud's phenomenon. Oral iloprost showed promise for preventing lung cancer in former, but not current, smokers in a phase II clinical trial. Maggie Fox. Reuters. 05/18/10.

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