Treatments for Pulmonary Arterial Hypertension: PDE-5 Inhibitors: Tadalafil (ADCIRCA®)

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer


Tadalafil is also known as ADCIRCA® and Cialis®. It's a pill taken once a day for PAH, and it improves exercise ability.

Tadalafil (ADCIRCA®, Cialis®) is a treatment for pulmonary arterial hypertension (PAH). (Also see: What is PAH?, What is Scleroderma? and PAH Treatments)

Tadalafil causes blood vessels to relax, thus improving circulation and reducing blood pressure in the lungs. It is also used to treat erectile dysfunction, under the brand name Cialis, but in much smaller doses than for PAH.

Tadalafil (ADCIRCA®) is a pill which is usually taken once a day for PAH. It is in a class of drugs called phosphodiesterase-5 Inhibitors (PDE 5 Inhibitors). ADCIRCA® (tadalafil) is manufactured by Eli Lilly and Company, and marketed by Lung Biotechnology PBC and United Therapeutics Corporation.

Combination Treatment

U.S. Food and Drug Administration Approves New Treatment Combination of Gileadís Letairis® with Tadalafil for Pulmonary Arterial Hypertension (WHO Group 1). The U.S. Food and Drug Administration (FDA) has approved the use of Letairis® (ambrisentan) in combination with tadalafil for the treatment of pulmonary arterial hypertension (PAH) (WHO Group 1) to reduce the risks of disease progression and hospitalization for worsening PAH, and to improve exercise ability. Gilead, 10/02/2015. (Also see: Letairis)

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