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Sjogren's Syndrome Research

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview Antibodies

Overview

Sjogren's research encompasses vital topics such as the causes, subtypes, biomarkers, genetics, antibodies, and progression.

Genetics in Sjögren's Syndrome. The genes associated with Sjögren syndrome (SS) can be assigned to the NF–kB pathway, the IFN signaling pathway, lymphocyte signaling, and antigen presentation. Rheumatic Disease Clinics, 06/21/2016.

Impact of the leucocyte immunoglobulin-like receptor A3 (LILRA3) on susceptibility and subphenotypes of systemic lupus erythematosus (SLE) and Sjögren's syndrome (pSS). Functional LILRA3 is a new susceptibility factor for SLE and pSS and it highly predisposes to certain phenotypes such as leucopenia, thrombocytopenia and autoantibody-positive subphenotypes. PubMed, Ann Rheum Dis, 2015 Nov;74(11):2070-5. (Also see Research on Systemic Lupus Erythematosus)

Update on the immunobiology of Sjögren's (pSS) syndrome. Progress made during the last few years on the pathogenesis of pSS has been mirrored by clinical trials directed at inhibiting cytokines, B, or T cell responses. PubMed, Current Opinion in Rheumatology, 08/04/2015. (Also see B cells and T cells)

A review of salivary gland histopathology in primary Sjögren's syndrome with a focus on its potential as a clinical trials biomarker. The role of histopathology as a biomarker for stratification and response to therapy is reviewed. PubMed, Ann Rheum Dis, 06/01/2015.

Salivary mucins induce a Toll-like receptor 4 (TLR4)-mediated pro-inflammatory response in human submandibular salivary cells: are mucins involved in Sjögren's syndrome (SS)? Salivary mucins were recognized by TLR4 in epithelial cells initiating a pro-inflammatory response and thereby contribute to the development of a chronic state characteristic of SS. PubMed, Rheumatology (Oxford), 03/22/2015.

Evaluation of Germinal Center (GC)-like Structures and B Cell Clonality in Patients with Primary Sjögren Syndrome with and without Lymphoma. GC-like structures seen in minor salivary glands may represent various subtypes of CD21+ infiltrates. A clear association between cellular infiltrates, B cell clonality, and lymphoma development was unable to be detected. PubMed, J Rheumatol, 2014 Oct 1.

Sjögren's syndrome (pSS): still not fully understood disease. Laboratory biomarkers and useful imaging tools for predicting the development of complications associated with Sjogren's. PubMed, Rheumatol Int, 2014 Jul 2.

Implication of Epstein-Barr virus (EBV) infection in disease-specific autoreactive B cell activation in ectopic lymphoid structures of Sjogren's syndrome (SS). Active EBV infection is selectively associated with ectopic lymphoid structures in salivary glands of Sjogren's syndrome and appears to contribute to local growth and differentiation of disease-specific autoreactive B-cells. PubMed, Arthritis Rheumatol, 2014 May 28. (Also see B Cells and T Cells)

Genome-wide association studies in Sjögren's syndrome (SS): What do the genes tell us about disease pathogenesis? Genetic findings are discussed with particular attention paid to the genes identified, the strength of associations, and how the SS-associated genes compare to what has been discovered previously in systemic lupus erythematosus (SLE). PubMed, Autoimmun Rev, 2014 Jul;13(7):756-761. (Also see Causes of Lupus: Genetics)

Early events in Sjögren's Syndrome pathogenesis: The importance of innate immunity in disease initiation. This review explores the relationship between innate immunity and SS pathogenesis prior to overt disease onset and discusses therapeutic strategies to mitigate disease progression. PubMed, Cytokine, 2014 Mar 19.

Genetics of Sjögren's syndrome in the genome-wide association era. Here we review the fundamental scientific principles employed in genome-wide association (GWA) scans as well as the limitations of this tool, and we discuss the application of GWA scans in determining genetic variants at play in complex disease. J Autoimmun, 2012 Jan 28.

Sjogren's Research: Antibodies

Etiopathogenic Role of Surfactant Protein D (SP-D) in the Clinical and Immunological Expression of Primary Sjögren Syndrome (pSS). High SP-D levels were found with severe glandular involvement, hypergammaglobulinemia, leukopenia, extraglandular manifestations, and positive anti-Ro/La antibodies. PubMed, J Rheumatol, 2014 Nov 1.

Sjögren's Antibodies (Anti-SS-A/Anti-SS-B). SS-A(Ro) is found in 60% to 70% of patients with Sjögren's syndrome and 30% to 40% of patients with SLE. SS-B(La) is found in 50% to 60% of Sjögren's syndrome and 10% to 15% of SLE. LabCorp.

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