Osteoporosis and Scleroderma
Osteoporosis is when the bone density is low causing the bones to become porous and prone to fractures. In scleroderma, bone density can decrease due to certain medications, a decrease in exercise, change in diet and factors of the disease itself. It is important to discuss this with your doctor, especially if you have a history of osteoporosis in your family. ISN.
Osteoporosis occurs when the rate of bone resorption exceeds the rate of bone formation creating "porous bones." Most cases of osteoporosis occur as an acceleration of this normal aging process. The condition can also be caused by other disease processes or prolonged use of certain medications that result in bone loss. Answers.com. (Also see Bone Resorption)
Significant bone microarchitecture impairment in premenopausal women with active celiac disease (CD). Patients with symptomatic CD had a greater bone microarchitectural deficit than those with subclinical CD. Bone, 03/14/2015. (Also see Celiac Disease)
Bone Density or Bone Mineral Density (BMD) is a measurement of the compactness of the bone or the amount of bone mass per square centimeter. Bone density measurements are used to diagnosis osteopenia, osteoporosis and fracture risk. ISN.
Proton pump inhibitors use and change in bone mineral density. The results of this study showed that PPI use in subjects without risk factors of osteoporosis determined by the femoral T–score compared with the control group was associated with increased risk of developing osteoporosis and osteopenia in the femur bones. Wiley Online Library, 05/31/2016.
Impact of treatment with inhaled corticosteroids (ICS) on bone mineral density (BMD) of patients with asthma: related with age. This study indicates that BMD reduction in ICS users with asthma is dependent on age and appears that younger patients are at greater risk of BMD loss. PubMed, Osteoporos Int, 04/10/2015. (Also see Asthma Treatments)
There is still a care gap in osteoporosis management for patients with rheumatoid arthritis. Although compliance with current osteoporosis guidelines remains low among all patients with rheumatoid arthritis, higher risk patients were more likely to have a bone mineral density test and receive treatment for osteoporosis. PubMed, Joint Bone Spine, 2014 Apr 2. (Also see Rheumatoid Arthritis)
Association between systemic sclerosis (SSc) and bone mineral density (BMD) based on twelve observational studies. We conclude that patients with SSc may have a lower BMD level than healthy controls. PubMed, Int J Rheum Dis, 2014 Jun 4.
Trabecular Bone Score (TBS) in Female Patients with Systemic Sclerosis (SSc): Comparison with Rheumatoid Arthritis and Influence of Glucocorticoid (GC) Exposure. SSc-related bone involvement is characterized by an impairment in bone quality in addition to reduced bone quantity, and TBS can identify the negative effect of GC on bone microarchitecture. PubMed, J Rheumatol, 12/01/2014. (Also see Osteoporosis and Glucocorticoids, Steroids (Prednisone)
Increased risk of osteoporotic fractures in patients with systemic sclerosis (SSc): a nationwide population-based study. SSc patients had a high increased risk of vertebral and hip fractures, especially those who were female, older, or used a high dose of corticosteroid (> 7.5 mg) or experienced bowel dysmotility. PubMed, Ann Rheum Dis, 2014 Feb 14. (Also see Steroid Warnings for Scleroderma)
Fracture Risk High in Systemic Sclerosis. Among the myriad potentially debilitating complications faced by patients with systemic sclerosis is an increased risk of osteoporotic fractures. Med Page Today, 02/19/2014.
Increased risk for bone loss in women with systemic sclerosis: a comparative study with rheumatoid arthritis. There is an increased risk for bone loss in patients with SSc and the risk of osteoporosis is associated with disease severity, prolonged menopause and disease duration. PubMed, Int J Rheum Dis, 2013 Nov 28.
Osteoporosis Treatments and Care. Osteoporosis treatments come in several forms. Many should be started during childhood; others include prescription drugs to treat osteoporosis. Get an overview. WebMD.
Treatment needs and current options for postmenopausal osteoporosis. The more recent advances in bone biology identified new targets for the development of drugs with a more potent and selective activity on either osteoclasts or osteoblasts. PubMed, Expert Opin Pharmacother, 04/07/2016.
Current approaches to osteoporosis treatment. Substantial progress has been made in the past several years in the understanding and modification of osteoporosis management. PubMed, Curr Opin Rheumatol. 2015 May;27(3):216-24.
Men's Bone Health Is Largely Ignored. A third of all hip fractures happen in men, and in the year after a fracture, men are twice as likely to die as women. Time Healthland, 10/10/2014.
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