Nailfold videocapillaroscopy can be used to assess the digital ulcer risk in people who have systemic sclerosis (SSc, scleroderma). Nailfold studies are also useful for diagnosis of systemic scleroderma. (Also see Fingernails, Fingerprints, Nailfolds, and Cuticles)
At–risk systemic sclerosis (SSc) patients can be identified using nailfold videocapillaroscopy ( NVC) a non–invasive imaging technique. The results supported the use of NVC as a routine strategy to evaluate patients with systemic sclerosis and to identify those at higher risks of disease progression and severity. Scleroderma News, 03/08/2016.
Late nailfold videocapillaroscopy (NVC) patterns associated with hand calcinosis and acro-osteolysis in systemic sclerosis (SSc). Acro–osteolysis and calcinosis are independently associated with the late NVC pattern, and particularly with severe capillary loss. PubMed, Arthritis Care Res (Hoboken), 07/20/2015. (Also see Bone Resorption in SSc and Calcinosis)
The relationship between nailfold capillaroscopic assessment and telangiectasia score with severity of peripheral vascular involvement in systemic sclerosis. Digital ulcer history and severe PVI in SSc were associated with capillary loss and microangiopathy. PubMed, Clinical and Experimental Rheumatology, 03/23/2015. (Also see Vascular Involvement and Telangiectasia)
Early systemic sclerosis (SSc): marker autoantibodies and videocapillaroscopy patterns are each associated with distinct clinical, functional and cellular activation markers. Autoantibody and microvascular patterns in early SSc may each be related to different clinical–preclinical features and circulating activation markers at presentation. Arthritis Research & Therapy, 29 May 2013, 15:R63 (Also see Antibodies in Systemic Scleroderma)
Capillaroscopic Skin Ulcer Risk Index (Csuri) In Systemic Sclerosis (SSc): Results From An Italian Multicenter Validation Study. This study confirms the high predictive value of capillaroscopic skin ulcers risk index, which is able to identify SSc pts at high risk to develop new digital ulcers. M. Sebastiani. EULAR 2011 OPO303. Ann Rheum Dis 2011;70(Suppl3):175.
The Hidden Contribution Of Macrovascular Involvement In The Cold Hands. This study confirms the high predictive value of capillaroscopic skin ulcers risk index, which is able to identify systemic scleroderma pts at high risk to develop new digital ulcers. M. Matucci-Cerinic. EULAR 2011 SP0210. Ann Rheum Dis 2011;70(Suppl3):56. (Also see Vascular Disease)
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