|Salt and Pepper Appearance
Ultraviolet Light Therapy
Systemic sclerosis (SSc) such as limited or diffuse scleroderma, can cause hyperpigmentation (darkening) and hypopigmention (lightening) of the skin, usually in the areas which have been affected by skin hardening. (Also see Overview of Skin Involvement, What is Scleroderma? and Types of Scleroderma)
Some medications, such as plaquenil and minocycline, can cause permanent dark skin plaques, which resemble black and blue marks similar to morphea scleroderma.
Cosmetically, pigmentation differences can be covered up with corrective cosmetics, such as Dermablend.
Hyperpigmentation associated with minocycline therapy. In one study, hyperpigmentation occurred in 41% of patients with rheumatoid arthritis who had been taking minocycline for more than 3 months (median onset 12 months). Canadian Medical Association Journal. (Also see Minocycline)
Plaquenil (Hydroxycholoroquine) Side Effects. Dermatologic side effects have included mucocutaneous hyperpigmentation, nonlight-sensitive psoriasis, bleaching of hair, alopecia, pruritus, photosensitivity, and skin eruptions such as urticarial, morbilliform, lichenoid, maculopapular, purpuric, erythema annulare centrifugum, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, and exfoliative dermatitis. Drugs.com.
Criteria for Diagnosis of Scleroderma. A "salt and pepper" pattern of hyperpigmentation (excess pigmentation of the skin) and hypopigmentation (reduced pigmentation of the skin) is common. MediFocus Health. (Also see Overview of Skin Involvement, What is Scleroderma? and Types of Scleroderma)
Ultraviolet Light Therapy Is as Beneficial for Darker Skin as Lighter Skin. An analysis of more than 100 patients has confirmed for the first time that darker-skinned patients benefit as those with lighter skin when given light therapy for morphea and related diseases. Newswise. UT Southwestern Medical Center. (Also see Morphea Treatments)
SCLERO.ORG is the world leader for trustworthy research, support, education and awareness for scleroderma and related illnesses, such as pulmonary hypertension. We are a service of the nonprofit International Scleroderma Network (ISN), which is a 501(c)(3) U.S.-based public charitable foundation, established in 2002. Meet Our Team, or Volunteer. Donations may also be mailed to:
International Scleroderma Network (ISN)
7455 France Ave So #266
Edina, MN 55435-4702 USA
Email [email protected] to request our Welcome email, or to report bad links or to update this page content.