Wound Healing in Systemic Scleroderma

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer


Wounds are supposed to heal — not stay the same or get worse.
So the choice is very simple — hire a doctor, or a hearse!

Wound healing can be a real challenge for many systemic scleroderma patients. Wounds include accidental cuts and abrasions, puncture wounds, and microvascular damage such as digital ulcers. Any wound that does not show improvement after a usual period of time should be brought to your doctor's attention.

They used to advise all scleroderma patients to avoid surgery whenever possible, due to concerns about wound healing. Now that is not a blanket recommendation, but rather is an issue to be considered on an individual basis. (Also see What is Scleroderma?, Digital Ulcer Treatments and Gangrene)

Fibroblasts in fibrosis: novel roles and mediators. In addition to the extensive extracellular matrix fibroblasts have multiple concomitant biological roles, such as in wound healing, inflammation, and angiogenesis, which are each interwoven with the process of fibrosis. Pub Med Front Pharmacol, 2014 May 27;5:123. (Also see Causes of Scleroderma: Fibroblasts)

Sticking it to Scleroderma: Potential Therapies Blocking Elevated Adhesive and Contractile Signaling. During repair of connective tissue, resting fibroblasts become `activated'; that is, they migrate into the wound where they synthesize and remodel new extracellular matrix. Leask, Andrew. (IngentaConnect) Current Enzyme Inhibition, Vol. 6, No. 2, July 2010, 97-104(8). (Also see Fibroblasts)

Medical Maggots™ (maggot therapy, maggot debridement therapy, MDT, biotherapy, biosurgery, biodebridement, larval therapy). Maggot therapy is the controlled, therapeutic use of live blow fly larvae ("maggots") to treat skin and soft tissue wounds. Monarch Labs.

Go to Xerosis (Dry Skin)
Recent Donors
See ISN News for recent donors, including memorials for
Christine Kane, Joleen M. Cascaden.

SCLERO.ORG is the world leader for trustworthy research, support, education and awareness for scleroderma and related illnesses, such as pulmonary hypertension. We are a service of the nonprofit International Scleroderma Network (ISN), which is a 501(c)(3) U.S.-based public charitable foundation, established in 2002. Meet Our Team, or Volunteer. Donations may also be mailed to:

International Scleroderma Network (ISN)
7455 France Ave So #266
Edina, MN 55435-4702 USA

Email [email protected] to request our Welcome email, or to report bad links or to update this page content.

TOLL FREE HOTLINE 800-564-7099
Free to U.S. and Canadian Callers. Ask for our Free Info Packet by mail or email!
Scleroderma, Pulmonary Arterial Hypertension, and related illnesses.
Privacy Policy.

The most important thing in the world to know about scleroderma is!
Donate Now
Copyright 1998-2017, International Scleroderma Network. AKA Scleroderma from A to Z and SCLERO.ORG. All Rights Reserved.