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Diagnosis of Linear Scleroderma

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview
Juvenile Scleroderma Experts
Blood Tests
Computerized Skin Score (CSS)
Ultrasonography
Severity Index
Also See

Overview

Diagnosis of Linear Scleroderma is usually done by clinical examination. It is often confirmed by skin biopsy. Skin biopsies are usually a very tiny sample of tissue and the procedure is often very quick, easy and with minimal discomfort. Ultrasound has also been found to be useful for the diagnosis of Localized Scleroderma (such as linear).

Juvenile Scleroderma Experts

Juvenile Scleroderma Experts. It is very important to consult a scleroderma expert for the proper diagnosis and treatment of scleroderma, because it is a rare disease. Treatments are available for most forms of localized scleroderma, but they are better at preventing progression than healing any damage that has already occurred. ISN. (Also see Linear Scleroderma Treatmentsand Scleroderma Experts)

Blood Tests

Serum Autoantibodies and their Clinical Associations in Patients with Childhood and Adult Onset Linear Scleroderma. Childhood onset Linear Scleroderma is similar to adult onset disease in regard to the frequency of serum autoantibodies. Thaschawee Arkachaisri. 289/289 ACR 2006. (Also see Antibodies)

Serum Autoantibodies and their Clinical Associations in Patients with Childhood and Adult Onset Linear Scleroderma (LScl). Childhood onset LScl is similar to adult onset disease in regard to the frequency of serum aAbs. Over two thirds of LScl patients had ANA. Thaschawee Arkachaisri. 289/289 ACR 2006. (Also see Antibodies)

Antihistone antibodies (AHAs) in linear scleroderma variants. AHAs, which traditionally are markers for drug-induced lupus, may also be linked to linear scleroderma. The AHA titers may be related to the extent of involvement as well as disease activity. PubMed, Int J Dermatol. 2006 Nov;45(11):1296-9. (Also see Antibodies)

Rheumatoid factor isotypes in localized scleroderma. The presence of RF isotypes is one of the immunological abnormalities of localized scleroderma. IgM RF seemed to be most useful of these three factors to determine the severity of disease. PubMed, Clin Exp Dermatol. 2005 Jul;30(4):405-8.

Computerized Skin Score (CSS)

A new computerized method for the assessment of skin lesions in localized scleroderma (LS). CSS (computerized skin score) has shown to be a reliable method to assess the skin lesions in patients with LS. It is reproducible, easy to use and, with the support of the CSS software, applicable worldwide. PubMed, Rheumatology (Oxford). 2007 Jan 30. (Also see Localized Scleroderma: Morphea)

Ultrasonography

Sonographic evaluation of pediatric localized scleroderma: preliminary disease assessment measures. We describe the range of sonographic differences found in pediatric LS, and present our efforts to standardize ultrasound acquisition and image interpretation for this disease. We present ultrasound measures that may aid evaluation of disease state. These assessments should be considered a work in progress, whose purpose is to facilitate further study in this area. More studies are needed to assess their validity and reliability. Suzanne C. Li. Pediatric Rheumatology, 2010, 8:14.

Severity Index for Localized Scleroderma

Localized Scleroderma (LS) Severity Index and Global Assessments: A Pilot Study of Outcome Instruments. LS clinical trials are impeded by the lack of reliable and reproducible outcome measures. We have developed the LS Severity Index (LoSSI) to correct this deficiency. Journal of Rheumatology.

Also See

Causes of Scleroderma. ISN.

Juvenile Scleroderma. ISN.

Scleroderma Photos. Pictures of scleroderma symptoms, including photos of Linear Scleroderma.

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