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Multiple Autoimmune Syndrome (MAS)

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer

Multiple Autoimmune Syndrome (MAS) is the coexistence of three or more autoimmune diseases. At least one of them is usually a skin disease, such as psoriasis or scleroderma.

The multiple autoimmune syndromes. A clue for the autoimmune tautology. Eight loci associated with multiple autoimmune syndrome (MAS) were observed harboring autoimmunity genes. The MAS represent the best example of polyautoimmunity as well as the effect of a single genotype on diverse phenotypes. PubMed, Clin Rev Allergy Immunol, 2012 Dec;43(3):256-64.

Introducing Polyautoimmunity: Secondary Autoimmune Diseases No Longer Exist. Polyautoimmunity is a term that can group all the taxonomy terms referring to coexistence of well-defined autoimmune diseases (ADs) in a single individual because some of the terms previously used are confusing and exclude various associations. NCBI. Autoimmune Dis, 2012; 2012: 254319. (Also see Overlap Syndromes)

Sjögren's syndrome at the crossroad of polyautoimmunity. This study discloses a high prevalence of polyautoimmunity in Sjogren's Syndrome, its associated risk factors and the grouping pattern of such a condition. PubMed, J Autoimmun, 2012 Jun 30. (Also see Sjogren's)

Psoriasis and concomitant fibrosing disorders: Lichen sclerosus, morphea, and systemic sclerosis. In this population, a predisposition toward autoimmunity is seen as 38.5% of patients had a personal history of a third concomitant autoimmune disease, in addition to psoriasis and fibrosing disorder, whereas 42.3% reported a history of a first-degree relative with an autoimmune disease. Journal of the American Academy of Dermatology Volume 67, Issue 5 , Pages 1079-1083, November 2012. (Also see Psoriasis, Lichen Sclerosus, Morphea, and Systemic Sclerosis)

(Case Report) A rare association of localized scleroderma (LS) type morphea, vitiligo, autoimmune hypothyroidism, pneumonitis, autoimmune thrombocytopenic purpura and central nervous system vasculitis. It is likely that localized scleroderma has an autoimmune origin and in this case becomes part of multiple autoimmune syndrome (MAS), which consist of the presence of three or more well-defined autoimmune diseases in a single patient. PubMed, BMC Res Notes, 2012 Dec 20;5:689 (Also see Causes of Morphea, Vitiligo, Hashimoto's Thyroiditis, Idiopathic Thrombocytopenic Purpura and Vasculitis)

Associated Autoimmune Diseases (AID) in Systemic Sclerosis (SSc) Define a Subset of Patients with Milder Disease: Results from 2 Large Cohorts of European Caucasian Patients. Our study shows that 21% of this large series of European Caucasian patients with SSc have developed at least 1 AID. This latter condition identified a subset of patients with milder disease. Thus, associations of AID and autoimmune background in SSc have to be considered for further therapeutic and biological investigations in SSc. Jerome Avouac. The Journal of Rheumatology March 1, 2010 vol. 37 no. 3 608-614.

Multiple Autoimmune Disease Genetics Consortium. MADGC is a group of leading genetic researchers who have joined efforts to identify and understand the genes that autoimmune diseases have in common. MADGC.

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