Scleroderma in Overlap

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overlap with Lupus
Overlap with Myopathies
Case Reports of Overlaps


When Systemic Sclerosis (in either the Limited or the Diffuse form) appears in conjunction with features of one or more other connective tissue diseases it is called "overlap." (Also see What is Scleroderma?)

Immunogenetics of systemic sclerosis (SSc): Defining heritability, functional variants and shared-autoimmunity pathways. The genetic overlap between SSc and other autoimmune diseases is explored. PubMed, October 2015.

Overlap Syndrome Distinct in Scleroderma (SSc). This study demonstrates that patients with SSc overlap, on average, carry a higher disease burden than patients with the Limited form. Medpage Today, 03/10/2015.

Scleroderma overlap syndrome. The incidence of additional connective tissue diseases in the whole group and in the overlap syndrome group respectively was: dermatomyositis or polymyositis 11.5% and 47.5%, Sjogren's syndrome 10.3% and 42.5%, rheumatoid arthritis 3.6% and 15.4%, and systemic lupus erythematosus 1.2% and 5.0%. Isr Med Assoc J, 2011. (Also see Dr. Balbir-Gurman)

Scleroderma in Overlap with Lupus

Disease progression in systemic sclerosis (SSc)-overlap syndrome is significantly different from limited (IcSSc) and diffuse cutaneous systemic sclerosis (dcSSc). SSc-overlap syndromes should be regarded as a separate SSc subset, distinct from lcSSc and dcSSc, due to a different progression of the disease, different proportional distribution of specific autoantibodies, and of different organ involvement. PubMed, Ann Rheum Dis, 2014 Jan 3.

An Immunochip based interrogation of scleroderma susceptibility variants identifies a novel association at DNASE1L3. This pilot study has confirmed previously reported scleroderma associations, revealed further genetic overlap between scleroderma and systemic lupus erythematosus, and identified a putative novel scleroderma susceptibility locus. PubMed, Arthritis Res Ther, 2014 Oct 21;16(5):438.

Scleroderma in Overlap with Myopathies

Clinical characteristics of scleroderma overlap syndromes (SOV): comparisons with pure scleroderma. SOV rather than pure scleroderma presented in younger Thai scleroderma patients and scleroderma–polymyositis overlap was the most common subtype and its clinical features were similar to those of pure scleroderma. PubMed, Int J Rheum Dis, 04/29/2016.

Clinical and laboratory features of overlap syndromes (OS) of idiopathic inflammatory myopathies associated with systemic lupus erythematosus, systemic sclerosis, or rheumatoid arthritis. This is the first study to show the different characteristics of a series of patients with connective tissue disease (CTD)-OS in the heterogeneous Brazilian population. PubMed, Clin Rheumatol, 07/04/2014. (Also see Myopathy and Myositis)

Case Reports of Scleroderma in Overlap

(Case Report) Sclerodermiform linear lupus erythematosus: A distinct entity or coexistence of two autoimmune diseases? The coexistence of features of chronic cutaneous lupus erythematosus and scleroderma in the same skin lesions is very infrequent and has only been reported in 3 patients. Journal of the American Academy of Dermatology. (Also see Lupus)

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