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Shared Autoimmunity

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer

Shared Autoimmunity is a rather loose term. It variously refers to autoantibodies, symptoms, or presence of autoimmune diseases within the same patient or within several or more members of the same family.

Bioinformatics-Based Predictions of Peptide Binding to Disease-Associated HLA Proteins Suggest Explanation for Shared Autoimmunity. The data suggest that, in susceptible individuals, shared autoimmunity might be initiated by two types of HLA/peptide interaction. Immunology and Immunogenetics Insights 2011:3 1-57.

Overlap syndromes in the context of shared autoimmunity. "Shared autoimmunity" is the term being used for the presence of autoimmune rheumatic diseases in several members of the same family, the concurrence of autoimmune rheumatic with non-rheumatic diseases in relatives of patients, the presence of autoantibodies in sera from healthy relatives of autoimmune-disease patients, the development of two or more autoimmune rheumatic diseases in one patient and the interplay of genetic and environmental factors leading to the presence of several autoimmune disease and/or their autoantibodies in families. PubMed, Autoimmunity. (Also see Causes of Scleroderma: Genetics)

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