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  2. Interleukin-17A biomarker as a predictor for detection of early axial spondyloarthritis (SpA) changes in patients with psoriasis. Our study can imply that IL-17A is a valuable, useful and low–cost biomarker in detecting early axial SpA changes in asymptomatic and nonradiographic axial SpA psoriatic patients. PubMed, Int J rheumatologist Dis, 10/05/2020. (Also see Interleukins and Psoriasis and Psoriatic Arthritis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  3. Last week
  4. Fatigue and its relationship with disease-related factors in patients with systemic sclerosis (SSc): a cross-sectional study. We recommend multidisciplinary approaches to evaluate and improve these parameters in the treatment of fatigue from the early period in SSc patients. PubMed, Turk J Med Sci, 09/15/2020. (Also see Fatigue) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  5. Hi Lisa, Welcome to these forums. I'm sorry to hear that you've been suffering for so long with such a plethora of different symptoms. Please note that I have no medical training and the symptoms you describe could relate to any number of health issues and not necessarily scleroderma or any connective tissue disease. The best person to advise you is your doctor/ endocrinologist when you have your next appointment and judging by the number of different symptoms you describe, it may be necessary for you to have further referrals to other specialists.
  6. 5 Things to Know About a COVID Vaccine: It Won’t Be a ‘Magic Wand ’. Even after a vaccine wins Food and Drug Administration approval, there would be a long wait before it’s time to declare victory over the virus. Kaiser Health News, 10/05/2020. (Also see Vaccinations) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  7. Blood–brain barrier (BBB) leakage in systemic lupus erythematosus (SLE) is associated with gray matter loss and cognitive impairment. Our findings provide evidence for a link between extensive BBB leakage and changes in both brain structure and cognitive function in patients with SLE. PubMed, Ann rheumatologist Dis, 10/01/2020. (Also see Symptoms and Complications of Lupus) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  8. Undifferentiated connective tissue disease at risk for systemic sclerosis (SSC): Which patients might be labeled prescleroderma? Predicting at onset which patients with Raynaud’s phenomenon are going to develop SSc over time has long been a research objective and still is an unaccomplished task. PubMed, Autoimmun Rev, 2020 Sep 14;102659. (Also see Undifferentiated Connective Tissue Disease) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  9. What Does ‘Negative’ on a Coronavirus Test Really Mean? It’s thus very possible to be antigen negative but P.C.R. positive, while still harboring the virus in the body. New York Times, 10/15/2020. This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  10. Hi. I’m very new to this forum & need some advice/support. I have been very sick for around 20 plus years with an illness that any Dr can't seem to diagnose. I have these horrible flares or exacerbations of the same symptoms over and over. Always exactly the same an now has affected my adrenal glands causing deadly low cortisol levels. I finally found an endocrinologist who is trying to help and is the first Dr that has listened. I accidentally came across some blood work from a Dr from 2012 where I had an equivocal Ana ( range 5-9) mine was 9 and then a positive an
  11. Prevalence of antimitochondrial antibodies in subacute cutaneous lupus erythematosus (SCLE). A high prevalence of AMA-M2 was found in patients with SCLE. PubMed, Int J Dermatol, 10/05/2020. (Also see Antibodies in Lupus) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  12. Hi Tony, I've never had TPE, so can't advise you from my own experience. I'm in the UK and frankly the chance of obtaining that particular treatment is negligible. From what I can gather, it's quite a invasive procedure and not something to be tried unless it's a fairly last resort. Your scleroderma expert is really the best person to advise you of any treatment needed. Kind regards,
  13. Thank you Joelf! Have you ever tried TPE yourself? It may be hard to convince doctors prescribe TPE, but do you think regular plasma donation may be some sort of "light version" of TPE? Unlike TPE, plasma donation is much easier to accomplish. Do you think in case when TPE is impossible plasma donation is better than nothing? Best regards,
  14. Changes in mental health symptoms from pre-COVID-19 to COVID-19 among participants with systemic sclerosis from four countries: A scleroderma patient-centered intervention network (SPIN) cohort study. Anxiety symptoms, but not depression symptoms, increased dramatically during COVID-19 among people with a pre-existing medical condition. Journal of Psychosomatic Research, 10/03/2020. (Also see Anxiety and Attitude) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  15. As dentists reopened in late spring, very few got Covid-19, survey finds. Early on in the pandemic, it was widely believed that dentists would be at high risk of contracting Covid-19. NBC Health News, 10/15/2020. (Also see Dental Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  16. Hi Tony, We do have a medical page on Therapeutic Plasma Exchange here, which I hope you'll find helpful and informative. Kind regards,
  17. Hello, Has anyone from this thread tried TPE as a treatment option? Do you still see that as a promising option, or your opinion changed since the last post? I want to convince my doctor to try that on me to see if that can help with my CREST and constant fatigue. If you are interested I can post my experience here. Best regards, Tony
  18. Earlier
  19. Hi Tony, We do have a lot of information about scleroderma in our medical pages here. Kind regards,
  20. Residual Disease Activity (RDA) and Associated Factors in Psoriatic Arthritis (PsA). RDA can be recognized in patients with PsA and very low disease activity seems to be the most stringent composite index to identify patients in the absence of RDA. PubMed, J Rheumatol, 2020 Oct 1;47(10):1490-1495. (Also see Psoriasis and Psoriatic Arthritis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  21. Hi Mary Sara, Thank you for the answer! Does methotrexate help you with fatigue a lot? I have a several issues related to CREST too but the most annoying are extreme fatigue and cognitive problems.
  22. Hi Joelf, Thank you! This forum and website overall is the real treasure! So much information doctors never have time to explain :) I think it's a bit offtopic to this thread, but not sure where to better ask for that: could you recommend some comprehensive literature (book or collection of articles) that explains all biological pathways involved in pathological scleroderma processes?
  23. Hi. I never got a notification that you posted on here. I came here to update that I still haven'tt had any symptoms of CREST. It's now been 6yrs since I found out I had a high anticentromere titer of 1:1280. I don't know what you mean by your titer being 4.7? . I'm 52 now. From what I've read online in terms of research, my high titer is only predictive of Scleroderma 82% of the time, meaning 18% of people like me who have the highest antibodies won't go on to get it. Now, I'm a realist, I could end up developing CREST symptoms in the next 10 seconds..but since I've had a positive
  24. TL1A Promotes Lung Tissue Fibrosis and Airway Remodeling. Reagents that disrupt the interaction of TL1A with DR3 then have the potential to prevent deregulated tissue cell activity in lung diseases that involve fibrosis and remodeling. PubMed, J Immunol, 2020 Sep 21;ji2000665. (Also see Pulmonary Fibrosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  25. Thank you for this! Informative B+ here so.......... *deep breath* *fingers crossed*
  26. BJMC, I have Raynauds, and it can be perplexing at times because you don't THINK it's "cold enough" to warrant the color changes. But from my experience it doesn't take much. I'm in an air-conditioned house set at 78degrees, and it can happen. Earlier this season I was in 90 degree pool temps and YEP, cold and white. I try to address it asap when it happens, as it is an indication of decreased blood flow, IMO the longer you decreased blood flow it may /can lead to other things (ulcers?) You can try warming them up with a heating pad, rubbing hands together or doing windmills with your
  27. Hi Tony It was a long time ago I was given steroids, I don't recall the dose. It was well before any diagnosis, tho. But what I've learned and is echoed by others is that steroid use with Sclero is risky. You should be monitored (from what I understand) for kidney involvement/ complications. I am currently on methotrexate as my symptoms could not be managed, pain gastrointestinal issues and fatigue. Now a year later I'm doing much better with all symptoms sans fatigue, although my tolerance for activity has improved.
  28. What's your blood type? It may affect your risk for Covid-19. A growing body of evidence suggests that blood type may play a role in the risk of becoming infected with the coronavirus or developing life-threatening complications from the illness. NBC Health News, 10/15/2020. This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
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