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  2. A Meta–Analysis of Treatment for Primary Sjögren's Syndrome. Reducing inflammation potentially improves salivary gland function. No individual immunomodulatory drug demonstrated consistent benefit in xerostomia and xerophthalmia. PubMed, Arthritis Care Res (Hoboken), 05/06/2019. (Also see Treatments for Symptoms of Sjögren's Syndrome) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  3. The International Scleroderma Network thanks Jack and Elizabeth Lewis for their monthly pledge support! Posted 06/16/2019.
  4. Interleukin-17 pathways in systemic sclerosis–associated fibrosis. There is multitude of evidence from across different tissues that interleukin-17 (IL-17) and its downstream pathways are strongly associated with the initiation and propagation of fibrosis. PubMed, Rheumatol Int, 05/09/2019. (Also see Interleukins and Skin Fibrosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  5. Glucosamine Tied to Heart Benefits. Glucosamine, the dietary supplement widely used for arthritic pain may reduce the risk for cardiovascular disease, researchers report. New York Times, 05/14/2019. (Also see Supplement Guide) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  6. The International Scleroderma Network thanks Gilead for their sponsorship support. Posted 06/14/2019.
  7. Hi AMDG, Welcome to these forums! I'm sorry to hear that you've been diagnosed with scleroderma and other unpleasant associated diseases. Blood test results can be tricky at the best of times and can fluctuate from test to test; even the results being taken from different laboratories can cause them to be positive, negative and back to positive again. Please see our sticky thread on the subject of blood test results. Of course, it's possible that the use of Rituxan could have improved things for you; the best person to advise you about this is your listed scleroderma expert (or failing that, a very good rheumatologist.) Kind regards,
  8. Soluble TNF-R1, VEGF and other cytokines as markers of disease activity in systemic lupus erythematosus (SLE) and lupus nephritis (LN). These results indicate that for active LN, sTNF-R1 could be a useful serum cytokine marker, with potential for vascular endothelial growth factor in the urine. PubMed, Lupus, 2019 May 2:961203319845487. (Also see Diagnosis of Lupus and Interleukins) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  9. Diagnosed with scleroderma, telangiectasia , sclerodactyly, Raynaud's, constantly puffy fingers, arthritis, arthralgia, excessive weight and muscle mass loss, fatigue, GI issues etc. Had positive ANA, then Positive SCL-70 twice. After 6 infusions of 4 hours each with Rituxan over 12 months, all blood work negative, skin softer, all else the same. Can Rituxan do that?
  10. Hi Lee, Welcome to these forums! Raynaud's does mainly affect fingers and other extremities in the cold weather, altough the fingers can turn red and purple as they warm up. Primary Raynaud's can occur on it's own and needn't necessarily be a symptom of scleroderma, although it does occur in the majority of scleroderma sufferers. However, I would suggest that if the hand symptoms you're experiencing are concerning you, you should make an appointment with your primary doctor, in order that further investigations into the problem can be made. Kind regards,
  11. I am new to all of this. The joints on my knuckles and fingers turn blue and purple in the cold, but I am now seeing they are turning a reddish pink in the heat in the same exact spots. I tried to google this but it just talks about Raynaud's and does Raynaud's effect your fingers in the heat or just the cold? Thank you very much. Lee
  12. Cytometric Characterization of Main Immunocompetent Cells in Patients with Systemic Sclerosis (SSc): Relationship with Disease Activity and Type of Immunosuppressive Treatment. In SSc patients, increment of T double positive and reduction of T double negative as well as natural killer and natural killer T cells were observed. PubMed, J Clin Med, 2019 May 8;8(5). (Also see Natural Killer Cells) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
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  14. The Debate Over Office Temperatures Just Heated Up, Thanks to a New Study. The question of how cold to keep an office often splits workplaces by gender, since women typically prefer a warmer workspace than men for reasons both biological and sociological. Time Healthland, 05/22/2019. This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  15. High levels of circulating interferons (IFNs) type I, type II and type III associate with distinct clinical features of active systemic lupus erythematosus. Our findings suggest that IFNs contribute to the heterogeneity of clinical manifestations in SLE, and measuring circulating IFNs could assist in designing clinical trials with therapies targeting IFN pathways. PubMed, Arthritis Res Ther, 2019 Apr 29;21(1):107. (Also see Diagnosis of Lupus) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  16. Would you like to help scientists find a cure for scleroderma? Dozens of clinical trials for scleroderma and pulmonary hypertension are actively recruiting now. Review them and be sure to ask your scleroderma expert about the ones you are interested in. (Also see Current Clinical Trials and Scleroderma Experts) Posted 06/09/2019.
  17. Validation of the REVEAL Prognostic Equation and Risk Score Calculator in Incident Systemic Sclerosis-Associated Pulmonary Arterial Hypertension. In predicting one–year survival in newly diagnosed SSc–PAH, the REVEAL prognostic equation and risk score provide very good discrimination but poor calibration. PubMed, Arthritis Rheumatol, 05/08/2019. (Also see Prognosis of Pulmonary Hypertension) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  18. Healthy maybe, but whilst I enjoy both in moderation, neither are so good for my GERD.
  19. Are Onions and Garlic Healthy? Here's What Experts Say. Garlic and onions are staples for many home cooks, but although they may not look like nutritional powerhouses, experts say they are. Time Healthland, 05/22/2019. (Also see Food Guide for Autoimmune Disease and Illnesses) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  20. Did you know you can help raise scleroderma awareness? The nonprofit International Scleroderma Network offers scleroderma awareness bracelets! Bracelets for just $2.50 each with free shipping and handling! They say "scleroderma" on one side and "sclero.org" on the other. (Also see Get Scleroderma Awareness Bracelets) Posted 06/07/2019.
  21. T cell receptor β repertoires (TCR) as novel diagnostic markers for systemic lupus erythematosus and rheumatoid arthritis. These characteristics of the TCR repertoire can potentially serve as biomarkers and provide novel insights for disease status and therapeutical targets in autoimmune diseases. PubMed, Ann rheumatologist Dis, 05/17/2019. (Also see Diagnosis of Lupus and Diagnosis of Rheumatoid Arthritis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  22. Patients with scleroderma require 'annual screening' for pulmonary arterial hypertension. Every patient with systemic sclerosis should be screened for pulmonary arterial hypertension every year, as early recognition, referral and aggressive treatment are necessary to improve long–term outcomes, according to Virginia Steen, MD. Healio Rheumatology, 05/22/2019. (Also see Pulmonary Hypertension Diagnosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  23. The International Scleroderma Network thanks United Therapeutics for their sponsorship support. Posted 06/06/2019.
  24. Mumps and measles cases in England prompt vaccine call. A significant increase in mumps cases and continuing outbreaks of measles in England have led to calls for people to ensure they are immunised. BBC News, 05/24/2019. This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  25. Prognostic Value of Microscopic Hematuria after Induction of Remission in Antineutrophil Cytoplasmic Antibodies–Associated Vasculitis. Hematuria at remission after a first pauci–immune glomerulonephritis flare was not associated with end–stage renal disease but with the occurrence of renal relapse within 44 months of remission. PubMed, Am J Nephrol, 2019 May 22;49(6):479-486. (Also see Vasculitis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  26. Shop at AmazonSmile and Amazon will make a donation to the nonprofit International Scleroderma Network. Posted 06/04/2019.
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