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  2. Early clinical markers of aggressive multiple sclerosis. These findings suggest that older age at symptom onset, greater disability during the first year, and pyramidal signs in the first year are early indicators of aggressive multiple sclerosis. PubMed, Brain, 05/09/2020. (Also see Multiple Sclerosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  3. Last week
  4. Nailfold Videocapillaroscopy (NVC) is a Useful Tool to Recognize Definite Forms of Systemic Sclerosis (SSc) and Idiopathic Inflammatory Myositis in Interstitial Lung Disease Patients (ILD). NVC should be considered in the diagnostic assessment of ILD patients regardless of the presence of Raynaud’s Phenomenon. PubMed, Diagnostics (Basel), 2020 Apr 25;10(5). (Also see Nailfold Videocapillaroscopy and Pulmonary Fibrosis Diagnosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  5. Shop at AmazonSmile and Amazon will make a donation to the nonprofit International Scleroderma Network. Posted 06/04/2020.
  6. Hi Dimarzio, It's quite an interesting article. I do hope you and your family are keeping well and virus free. Best wishes,
  7. These are serious observations Jo, especially for those of us with circulatory issues. If I end up in hospital with coronavirus, I think I will be asking for anticoagulants whilst I am still in a fit state to do so.
  8. Alarmed as COVID patients' blood thickened, New York doctors try new treatments. As the novel coronavirus spread through New York City in late March, doctors at Mount Sinai Hospital noticed something strange happening to patients’ blood. Reuters Health, 04/22/2020. This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  9. Adult Vulvar Lichen Sclerosus: Can Experts Agree on the Assessment of Disease Severity? Standardized descriptions regarding what constitutes mild, moderate, and severe signs and anatomical changes are required before further scale development can occur. PubMed, J Low Genit Tract Dis, 03/20/2020. (Also see Lichen Sclerosus) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  10. The International Scleroderma Network thanks Actelion Pharmaceuticals US, Inc. for their sponsorship support. Posted 06/02/2020.
  11. CD21low B cells in systemic sclerosis: A possible marker of vascular complications. CD21low B cells are increased in SSc patients with visceral vascular manifestations. PubMed, Clin Immunol, 2020 Apr;213:108364. (Also see Vascular Involvement and B Cells and T Cells) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles
  12. What can coronavirus antibody tests actually tell us? Assuming that positive antibody test results confer immunity is a "very dangerous conclusion," say experts. NBC Health News, 04/21/2020. (Also see Autoantibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  13. Comparative Risk of Cardiovascular Events (MACE) With Biologic and Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) in Patients With Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. Based on meta-analysis, as compared to tumor necrosis factor inhibitors, tocilizumab may be associated with a reduced risk of MACE, whereas csDMARDs may be associated with an increased risk of MACE and stroke. PubMed, Arthritis Care Res (Hoboken), 2020 Apr;72(4):561-576. (Also see DMARDs and Treatments for Rheumatoid Arthritis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  14. Earlier
  15. Late Gadolinium Enhancement (LGE) in Cardiac Magnetic Resonance Imaging Is Associated with High Renal Resistive Index (RRI) in Patients with Systemic Sclerosis. Our study, showed RRI and LGE as markers of vascular and fibrotic damage. PubMed, Kidney Blood Press Res, 2020;45(2):350-356. (Also see Kidney Involvement and Heart Complications) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  16. Latest on the spread of the coronavirus around the world. Reported cases of the coronavirus have crossed 2.5 million globally and 177,004 people have died, according to a Reuters tally. Reuters Health, 04/22/2020. This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  17. Treatments of osteoporosis increase bone material strength index (BMSi) in patients with low bone mass. In patients at increased fracture risk, antiresorptive treatments induced BMD-independent increases in BMSi values, the magnitude of which depended on pretreatment values. PubMed, Osteoporos Int, 04/08/2020. (Also see Osteoporosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  18. Ultrasound Surface Wave Elastography for Assessing Scleroderma (SSc). We will further study if skin viscosity is sensitive enough to detect early edema from inflammation changes of SSc. PubMed, Ultrasound Med Biol, 2020 May;46(5):1263-1269. (Also see Skin Viscoelasticity) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  19. 'Thousands missing out on cancer diagnosis'. Delays in diagnosing and treating people with cancer could lead to more years of lost life than with Covid-19, according to a leading cancer expert. BBC Health News, 04/22/2020. (Also see Cancer) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  20. Serum levels of soluble programmed cell death protein 1 (sPD1) and soluble programmed cell death protein ligand 2 (sPD-L2)are increased in systemic lupus erythematosus (SLE) and associated with the disease activity. The present study demonstrated the association of serum sPD-1 and sPD-L2 with SLE and suggests their usefulness as disease activity biomarkers for SLE. Sage Journals, Lupus, 04/07/2020. (Also see Systemic Lupus Erythematosus) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  21. Silica Exposure and Scleroderma: More Bridges and Collaboration between Disciplines Are Needed. The lack of a proper understanding of the pathogenesis of silica-associated autoimmunity may also result from missing bridges between disciplines. PMC, Am J Respir Crit Care Med, 2020 Apr 1; 201(7): 880–882. (Also see Silica Exposure) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  22. Coronavirus: How to combat back pain while working from home. Working from home, there are likely to be inconsistent desk set-ups where injuries are more likely. BBC Health News, 04/21/2020. This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  23. Complement deposition, C4d, on platelets is associated with vascular events in systemic lupus erythematosus (SLE). PC4d+ is associated with vascular events in SLE, independently of traditional and SLE-associated risk factors. PubMed, Rheumatology (Oxford), 04/07/2020. (Also see Symptoms and Complications of Lupus) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  24. Antigen-specific (Ab) humoral responses against Helicobacter pylori (Hp) in patients with systemic sclerosis (SSc). Anti-Hp Abs are neither more frequent nor elevated in SSc compared with healthy population and these results suggest that Hp is unlikely to be involved in the development of SSc. PubMed, Immunol Res, 04/06/2020. (Also see Antibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  25. The International Scleroderma Network thanks Genentech for their sponsorship support. Posted 05/21/2020.
  26. Almost Every Hospitalized Coronavirus Patient Has Another Underlying Health Issue. A new study of people in the New York City area who have been hospitalized with COVID-19 reveals that most of them have more than one underlying illness. Time Healthland, 04/22/2020. This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  27. Electrodiagnostic Abnormalities Associated with Fibromyalgia. In addition to skin punch biopsies to assess small fiber neuropathy, assessment of the anal reflex may be a useful part of the diagnostic pathway in patients with fibromyalgia. Dovepress, Journal of Pain Research, 04/09/2020. (Also see Fibromyalgia) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  28. Case Report: COVID-19 in a patient with systemic sclerosis (SSc) treated with tocilizumab for Ssc-interstitial lung disease (ILD.) Our case indicates that IL-6-blocking treatment given for chronic autoimmune diseases may even prevent the development of severe COVID-19. BMJ Journals, Ann rheumatologist Dis. (Also see Clinical Trials) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
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