Anticentromere antibodies decrease in Sclero Forums (MAIN) Posted Monday at 07:50 PM Hi Tate, Welcome to Sclero Forums! There's one aspect of your post missing. That is, scleroderma is never diagnosed based only on blood work. The diagnosis depends upon the presence of certain symptoms or a constellation of symptoms, which I presume were the reasons you had the blood test run in the first place. With the right symptoms, you can be diagnosed with scleroderma without any positive blood work at all. By the same token, you cannot be "undiagnosed" with scleroderma just because an antibody returns to normal. Many people experience changes in their antibodies over time, if their doctors persist in testing for them. Perhaps its good if antibodies return to normal, or interesting if another antibody suddenly shows up, but the real question is whether your overall health is worsening, staying the same, or getting better. For me, I wouldn't read too much into antibodies. They can help during the diagnosis stage, but most of them don't directly tie in with the disease or help with managing the progression. It's possible to die of scleroderma while having entirely normal antibodies; and it's possible to live with scleroderma for many decades despite very impressive antibodies. You haven't mentioned your symptoms worsening, so I may presume they are stable. And with your treatment plus a bit of luck too, maybe they will stay that way!