What should I expect next? in Sclero Forums (MAIN) Posted November 11, 2015 · Report reply Hi Jazi, Welcome to Sclero Forums. I'm sorry you have scleroderma with gastrointestinal involvement. I'm not sure its much of a comfort to say that's there's no predictable pattern with the development of scleroderma symptoms. It's sort of a catch-22, that most of us have no idea what to expect next. Another confounding thing is that the natural course of scleroderma is to wax and wane. That is, it gets worse -- and then better, even without any treatment at all! That aspect is so strange that it makes discovering treatments very difficult. Researchers are just positive they've found a useful treatment, only to find out way down the line that it was only the natural course of scleroderma they were witnessing, and not the result of their grand treatment. Therefore, one of the biggest challenges of scleroderma is to wrap our head around the idea that things could take a turn fo the worse any day...or, they might linger or even improve over the next forty or fifty years. Should we worry? What should we worry about? Should we not worry at all, and throw all caution to the wind? What I've found is that worry doesn't help any of us at all. Neither does tuning it all out and throwing all caution to the wind. But, educating ourselves on the illness, becoming aware of potential pitfalls but not agonizing over the prospect, and developing sturdy attitudes that can see us through thick or thin can be very helpful indeed!