I Need My Sclero Sleuths in Sclero Forums (MAIN) Posted March 23, 2016 Hi Miocean, If it's definitely not skin tightening from scleroderma, then it may be peripheral neuropathy/parasthesias and/or edema, perhaps caused by uremic neuropathy, given your kidney failure. If I were you, I think I'd see my nephrologist about this, before changing any medications. Both the pain patch and plaquenil are probably more likely to be helpful than harmful for you right now. I can understand looking askance at the newest medications first (I always do that, too!), but in this case, you might want to have your doctors take a second look at the underlying illness(es), as well. Of course, that's just my two very uneducated cents, which isn't even enough to buy penny candy anymore!