Protein in Urine - Can Anybody Relate? in Sclero Forums (MAIN) Posted September 2, 2016 Hi Wilson, Well, you raised an excellent question. Here's a comprehensive article, Proteinuria in Adults: A Diagnostic Approach by American Family Physician. As you can see, figuring out the cause is quite complicated but it needs to be taken step by step. There are many things that can give it a false positive, so usually they are concerned about the overall pattern, rather than a single test. That article includes a flow chart, which is very helpful in sorting out how to proceed with the diagnosis. Scleroderma would be a very rare cause of kidney failure, of course, simply because it is so rare, whereas hypertension and diabetes would be far more common causes. And, even people with scleroderma can acquire diabetes (etc.), so everything needs to be considered in the beginning. I hope that your doctors are able to sort it out soon for you!