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Joelf

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About Joelf

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  1. Hi Charwim, Welcome to these forums! I've included a link to our medical page on CREST syndrome, which I hope you'll find helpful and interesting. Regarding your blood test results, please see our sticky thread here. Kind regards,
  2. Type I interferon dysregulation in Systemic Sclerosis. Here we describe the evidence of Type I IFN dysregulation in SSc, revealed predominately by genetics and gene expression profiling. PubMed, Cytokine, 01/23/2019. (Also see Cytokines) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  3. The International Scleroderma Network thanks Jack and Elizabeth Lewis for their monthly pledge support! Posted 03/16/2019.
  4. Doing Physical and Mental Exercise When You’re Younger May Help Ward Off Dementia. Researchers say that what you do when you are younger — including activities like reading and gardening — can affect your risk of developing dementia and Alzheimer's disease. Time Healthland, 02/20/2019. This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  5. Hi Ian, Welcome to these forums! I'm sorry to hear that so far the MTX hasn't been of any help to you. I've never taken this medication, so can't advise you from my own experience. However, many of our members have taken it with varying degrees of success, so hopefully things will improve for you and you'll start to feel much better very soon. Kind regards,
  6. Usefulness of composite indices in the assessment of joint involvement in systemic lupus erythematosus (SLE) patients: correlation with ultrasonographic score. We suggest the ability of composite indices in detecting SLE joint inflammation and their possible real–life use. PubMed, Lupus, 2019 Feb 11:961203319828527. (Also see Symptoms and Complications of Lupus) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  7. The International Scleroderma Network thanks Gilead for their sponsorship support. Posted 03/14/2019.
  8. Incidental significant arrhythmia in scleroderma (SSc) associates with cardiac magnetic resonance measure of fibrosis and hs-TnI and NT-proBNP. This first implantable loop recorder study identified potentially life–threatening arrhythmias in asymptomatic SSc patients attributable to a primary SSc heart disease. PubMed, Rheumatology (Oxford), 01/28/2019. (Also see Complications with SSc Heart Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  9. Hi Tennille and OzzieGuy, Welcome to these forums! I'm sorry to hear that you are both experiencing worrying symptoms. Although your doctor has advised that Raynaud's could be the cause of your purple nail beds, I must admit that it's not a particular symptom I have encountered (and I've had Raynaud's for many years). Of course, it can be a symptom of many other diseases and wisely I see that you've both had the obvious heart, chest x-ray etc. to rule out those serious problems. Tennille: Even supposing that you do have Raynaud's, it doesn't necessarily follow that you will develop scleroderma. Many people suffer with primary Raynaud's which never develops into anything more and the fact that you don't have any other symptoms, could possibly mean that, in your case, it never will. However, please note that I have no medical training and therefore the best person to advise you of any further action to be taken is your doctor. As OzzieGuy has advised the best person to treat complicated diseases such as scleroderma is a listed scleroderma expert. OzzieGuy: I do hope you will be able to obtain a diagnosis; unfortunately scleroderma is notoriously difficult to diagnose correctly, as many of our members can testify. Kind regards,
  10. Asthma: Young people in the UK 'more likely to die'. Young people in the UK are more likely to die from asthma than those in other wealthy countries, a report has found. BBC Health News, 02/20/2019. (Also see Asthma) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  11. Hi WRC 1000, Welcome to these Forums! I'm very pleased to hear that (so far) you've escaped the unpleasant symptoms of scleroderma, despite having positive blood tests. This does emphasise the advice we always give, regarding the importance of blood tests in the diagnostic process. Kind regards,
  12. Investigating asthma, allergic disease, passive smoke exposure, and risk of rheumatoid arthritis (RA). Asthma and allergies may be associated with increased risk of RA, although passive smoke exposure and earlier age of starting smoking do not appear to influence risk of RA. PubMed, Arthritis Rheumatol, 02/12/2019. (Also see Causes of Rheumatoid Arthritis and Asthma) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  13. Would you like to help scientists find a cure for scleroderma? Dozens of clinical trials for scleroderma and pulmonary hypertension are actively recruiting now. Review them and be sure to ask your scleroderma expert about the ones you are interested in. (Also see Current Clinical Trials and Scleroderma Experts) Posted 03/09/2019.
  14. Hi JS1616, Welcome to these forums! For information regarding your blood tests, please see our sticky thread here. As to whether having another child will cause your blood test results to change, I'm afraid it really is impossible to say (which is probably why your doctors have been unable to advise you and have suggested that as you have not had any problems previously, you should go ahead with another pregnancy, should you so desire.) Blood test results can be different each time they are taken (and can even have different results from different laboratories.) The only thing you can do is become pregnant and see what happens! Kind regards,
  15. PU.1 controls fibroblast polarization and tissue fibrosis. Pharmacological and genetic inactivation of PU.1 disrupts the fibrotic network and enables reprogramming of fibrotic fibroblasts into resting fibroblasts, leading to regression of fibrosis in several organs. PubMed, Nature, 01/30/2019. (Also see Fibroblasts) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
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