Has anyone had a late or slow onset of diffuse skin involvement? in Sclero Forums (MAIN) Posted February 24, 2015 Thanks for the replies. I put a lot of faith, maybe too much, in antibody testing and statistics. While I know that they are not the absolute "truth" and there are exceptions, numbers and trends tend not to lie. I definitely feel better than I did this time last year, but the uncertainty of this disease is awful. The fact remains that men tend to have a worse outcome than women and my antibody type (U3RNP) is extremely rare, tends to have one of the worst mortality rates due to a high incidence of isolated Pulmonary Arterial Hypertension regardless of skin involvement. With that being said, I do agree with you Shelley about people categorizing themselves as either diffuse or limited. I also have read from someone that once said "this disease presents itself early" and I'm clinging to that. Regardless, I am still adopting an approach to be as aggressive with treatment as my doctors will allow.