Just got done with seeing my Sclero specialist in Sclero Forums (MAIN) Posted November 18, 2014 Well this is the 3rd week of Methotrexate. It is not a fun drug to be on. Nothing like a cold rainy monday morning after MTX. I may ask if I can be switched to Cellcept. As far as the renal crisis goes I have been testing my urine at home with those dipsticks and sometimes they are coming up showing protein in urine. Pee is usually bubbly too. I am going for a 24 hour urine test this week. My GFR is 112, and my serum levels were all good last blood work, but the fact that the home dispsticks are showing up with protein is not reassuring. I know the Prednisone could do this, and am currently in the process of tapering it, but can MTX also cause kidney issues? I know Cellcept is usually prescribed if lung damage or kidney damage is present. I will have to confer with sclero specialist.