Long Odds in Sclero Forums (MAIN) Posted February 7, 2016 Am I correct in understanding that Systemic Sclerosis affects 1 in 10,000 people and that 6 out of 7 sufferers are female? If that is the case, the chances of a male getting it are 70,000 to 1 - that's incredibly long odds isn't it? Does anyone know of any other statistics or probability info? Is there any data on the probability of the limited form becoming diffuse? I have esopheagul, stomach and bowel involvement as well as a lot of aches and pains plus some odd skin patches developing on my shoulders, though to be honest, apart from my skin feeling thick and odd, it's not causing any dis-comfort at the moment. - does all of this indicate limited or diffuse? I've read some stuff that says nobody knows what causes this disease (other than the immune system not turning off), some suggest an inherited pre-disposition (though I've never come across anyone with the disease until now), I've read some stuff suggesting links with vinyl chloride and heavy metals, and some suggesting lifestyle, though these seem fairly tenuous. Are there any other studies suggesting possible causes?