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CraigR

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Posts posted by CraigR


  1. Sjögren’s syndrome, the old and the new. An extensive review the postulated aetiologies, pathogenesis and new insights related to Sjögren’s syndrome. Best Pract Res Clin Rheumatol. 2012 Feb;26(1):105-17. (Also see: Sjogren's)

     

    This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

    Craig Roothoff

    ISN Assistant News Guide

    International Scleroderma Network(ISN)


  2. After my appointment on 7-10 I had more bloodwork that was still negative for muscle enzyme and high sed and CRP rates, though there was improvement. I am setting up an appointment with a neurologist. There has been improvement, but too slow for me!

     

    For a quite a while I've suspected some sort of neurological damage from cancer chemotherapy, since my balance was so bad that I required a cane, in spite of a great deal of exercise

     

    So we will see.

     

    Craig


  3. Thanks for the info. I see my rheumatologist tomorrow and this is good for discussion. I am slowly improving (but not nearly fast enough...) I don't know that a nerve disorder such as sciatica would cause high inflammation (my only positive tests were a very high SED rate and high CRP), which points more toward MS or MG. The symptoms sound much like MG, but were legs only. Oddly, I have had attacks in my upper body (to the point of pain making breathing difficult), but never upper and lower body at the same time.

     

    Craig


  4. Intensity and Duration of Anticoagulation Therapy in Antiphospholipid Syndrome. A recent consensus document recommends warfarin to an INR range of 2.0 to 3.0 for patients with a first venous thromboembolic event. Higher anticoagulation intensity is recommended for patients presenting with arterial events. Semin Thromb Hemost. 2012 Mar 30. (Also see: Antiphospholipid Syndrome)

     

    This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

    Craig Roothoff

    ISN Assistant News Guide

    International Scleroderma Network(ISN)


  5. I've developed a severe muscle disorder in my legs over the past 2 months. Following a cold with a persistent cough, I developed severe back pain that soon became great leg pain - especially when moving then (little pain when resting). My rheumatologist suspected myositis, but muscle enzyme tests came back normal. I've had myalgia/myositis issues in the past, but of the upper body.

     

    At the worst, It took heavy pain relievers and 80 mg of prednisone a day just to make it possible to get out of a chair. All tests were normal except ESR ( erythrocyte sedimentation rate) and CRP (C-reactive protein) which were highly elevated. My rheumatologist thinks the muscle enzyme test may have been falsely negative due to taking prednisone. I have reduced medication since that time.

     

    The critical stage has passed, but I require a walker to get around, due to weakness and ongoing inflammation and it doesn't seem to be improving. I would like to find out who might be an expert on such matters. Light exercise does not seem helpful since it increases pain.

     

    My history is slow-onset sclero with Sjogren's and pulmonary hypertension. My latest autoimmine panel oddly did not show any sclero antibodies, but showed both Sjogren's antibodies.

     

    Anybody had anything similar?

     

    Craig


  6. Short-term and long-term consequences and concerns regarding valid assessment of vitamin D deficiency: comparison of recent food supplementation and clinical guidance reports. Healthcare providers should formulate their own opinions with respect to vitamin D as it pertains to the care of their patient. PubMed. Curr Opin Clin Nutr Metab Care. 2011 Sep 19. (Also see: Supplement Guide for Scleroderma)

     

    This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

    Craig Roothoff

    ISN Assistant News Guide

    International Scleroderma Network(ISN)


  7. Infectious diseases and autoimmunity. Besides genetic predisposition to autoimmunity, viral and bacterial infections are known to be involved in the initiation and promotion of autoimmune diseases. PubMed. Journal of Infection in Developing Countries. 2011 Oct 13;5(10):679-87.

     

    This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

    Craig Roothoff

    ISN Assistant News Guide

    International Scleroderma Network(ISN)


  8. A current perspective on Sjögren's syndrome. Recent developments are unlocking the mystery of the disease process as well as contributing to our ability to define, diagnose, and develop new treatment modalities for patients with this complex disorder. PubMed. J Calif Dent Assoc. 2011 Sep;39(9). (Also see: Sjogren's Syndrome )

     

    This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

    Craig Roothoff

    ISN Assistant News Guide

    International Scleroderma Network(ISN)


  9. Autoimmune disease and gender: Plausible mechanisms for the female predominance of autoimmunity. Hormonal changes as well as the genetic factors that could explain why women are more prone to develop autoimmune diseases are reviewed. Journal of Autoimmunity, 2011 Nov 11. (Also see: Autoimmunity)

     

    This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

    Craig Roothoff

    ISN Assistant News Guide

    International Scleroderma Network(ISN)


  10. Liver complications in celiac disease. Information regarding liver disorders that may be found in association with celiac disease and the effect of the treatment of celiac disease on these disorders. Hepatitis Monthly, 2011 May 1;11(5):333-341. (Also see: Celiac Disease)

     

    This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

    Craig Roothoff

    ISN Assistant News Guide

    International Scleroderma Network(ISN)


  11. Antiphospholipid syndrome in obstetrics. The clinical hallmarks of this syndrome are thrombosis and poor obstetric outcomes, including miscarriages, fetal loss and severe pre-eclampsia. Best Pract Res Clin Obstet Gynaecol. 2011 Nov 10. (Also see: Antiphospholipid Syndrome)

     

    This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

    Craig Roothoff

    ISN Assistant News Guide

    International Scleroderma Network(ISN)


  12. Aluminum as an adjuvant in Crohn's disease induction. Aluminum is a potential factor for the induction of inflammation in Crohn's disease. PubMed. Lupus. 2012;21(2):231-8. (Also see: Inflammatory Bowel Disease)

     

    This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

    Craig Roothoff

    ISN Assistant News Guide

    International Scleroderma Network(ISN)


  13. Vaccine model of antiphospholipid syndrome induced by tetanus vaccine. Successful induction of antiphospholipid syndrome (APS) in two different non-autoimmune prone mouse strains, was achieved by tetanus toxoid hyperimmunization. PubMed. Lupus. 2012;21(2):195-202. (Also see: Antiphospholipid Syndrome)

     

    This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

    Craig Roothoff

    ISN Assistant News Guide

    International Scleroderma Network(ISN)


  14. Autoimmune response following influenza vaccination in patients with autoimmune inflammatory rheumatic disease (AIRD). Although seasonal and H1N1 vaccines are safe and effective, they also have the potential to induce autoantibodies in selected AIRD patients and healthy adults. PubMed. Lupus. 2012;21(2):175-83. (Also see: Causes of Scleroderma: Vaccinations)

     

    This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

    Craig Roothoff

    ISN Assistant News Guide

    International Scleroderma Network(ISN)


  15. EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases. Recommendations for vaccination in patients with AIIRD based on the currently available evidence and expert opinion were formulated. More research is needed, particularly regarding the incidence of vaccine-preventable infectious diseases and the safety of vaccination in patients with AIIRD. Ann rheumatologist Dis doi:10.1136/ard.2010.137216. (Also see: Causes of Scleroderma: Vaccinations)

     

    This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

    Craig Roothoff

    ISN Assistant News Guide

    International Scleroderma Network(ISN)


  16. Th17 Response and Inflammatory Autoimmune Diseases. Preclinical and clinical data show that Th17 cells are associated with several autoimmune diseases such as arthritis, multiple sclerosis, psoriasis, and lupus. International Journal of Inflammation Volume 2012, Article 819467. (Also see: Causes of Scleroderma: T Cells)

     

    This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

     

    Craig Roothoff

    ISN Assistant News Guide

    International Scleroderma Network(ISN)


  17. Effect of autoimmune diseases on mortality and survival in subsequent digestive tract cancers. Patients with some autoimmune diseases (AIDs) are at increased risk of cancer, possibly a result of an underlying dysregulation of the immune system, medication, or treatment (and not by surveillance bias). Annals of Oncology, 11/22/11. (Also see: Cancer and Scleroderma)

     

    This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

     

    Craig Roothoff

    ISN Assistant News Guide

    International Scleroderma Network(ISN)


  18. Prevalence of celiac disease among first degree relatives of celiac disease patients. Given the high prevalence (4.8%) of the disease in this specific group, it is suggested that an extensive screening policy be mandatory for these subjects. J Pediatr Gastroenterol Nutr. 2012 Jan 10. (Also see: Celiac Disease and Gluten Sensitivity)

     

    This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

     

    Craig Roothoff

    ISN Assistant News Guide

    International Scleroderma Network(ISN)


  19. I'm inclined to agree with Amanda. I manage my care. I am happy that my primary care physician is concerned to remind me of who I should be seeing, etc., but to expect him to become interested in my disease is doesn't seem reasonable, since our diseases are so rare. It's a bit like expecting your auto mechanic to take an interest in your 1923 Pierce Arrow, rather than send you to the antique car restorer.

     

    As for being able to get in to see your primary care physician - that is another story. I can usually get in within a day or two. That shouldn't be so difficult. Of couse the different plans make for their unique challenges. I've always preferred PPO (Preferred Provider Organizations) plans, since I can manage and coordinate my care without going through the primary care physician.

     

    Craig


  20. Systemic Autoimmune Diseases and Depressive Disorders. A very elevated prevalence of depression of 69% was found in systemic autoimmune diseases, constituting the most frequent comorbidity. Depression was significantly associated with pain, fatigue and sleep disorders. PubMed. Reumatol Clin. 2011 Nov;7(6):389-91. (Also see: Depression)

     

    This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

     

    Craig Roothoff

    ISN Assistant News Guide

    International Scleroderma Network(ISN)


  21. I've has Sjogrens's for about 12 years. It effects my mouth worse than eyes. At night, I frequently wake up with a mouth so dry that it has become painful. Biotene mouthwash seems to help with this pain/inflammation. Eyes are usually only effected when stressed, such as driving long distances. Sort of odd, since the Schirmer test gave me a 1 (or slightly less!).

     

    Oral hygiene is very important, since the flow of saliva has a cleaning/disinfecting effect on the mouth. I like to always keep a glass of water available to sip from time to time.

     

    I take Evoxac at night, which (I'm told is supposed to be more effective than Salagen [but since it doesn't help much, I have my doubts]).. I believe it is classified as a "cholinergic agonist". No side effects. Among several other drugs, I take Plaquenil, which doesn't seem to effect the Sjogren's. Many drugs and supplements make dyness worse, so it is good to review any of these with your doctor so as to avoid taking anything with a "cholinergic antigonist" effect. Definitely never drooled (though that would probably mean it's working!)

     

    As for not taking eye drops. I presume it is ihe eye pain I experience is tthe same as dry, painful eyes that anyone would get. I haven't had it to the point of grittiness.

     

    If he chooses not to take drops, then so be it. They are a great relief to dry eyes (even for those without Sjogren's!). There are many good product available. A doctor might recommend something best. I prefer one of the high quality thicker solutions especially for dry eye. If you haven't already, you might acquire some so it is available should be he change his mind.

     

    Good luck

     

    Craig


  22. High Prevalence of Systemic Autoimmune Diseases in Patients with Menière's Disease. Despite some limitations, Meniere's Disease (MD) displays an elevated prevalence of systemic autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and ankylosing spondylitis (AS). PLoS One. 2011;6(10):e26759. (Also see: Autoimmune Ear Disease)

     

    This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

     

    Craig Roothoff

    ISN Assistant News Guide

    International Scleroderma Network(ISN)


  23. Are autoimmune diseases predictable? In the future, multiple antibodies test, in combination with the analysis of genetics, epigenetics and immunological anomalies in fine models may allow the precise prediction in autoimmune diseases. GJ Autoimmun Rev. 2011 Oct 7.

     

    This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

     

    Craig Roothoff

    ISN Assistant News Guide

    International Scleroderma Network(ISN)

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