Boosting Immunity in Sclero Forums (MAIN) Posted June 17, 2016 Judy, I just read this about MBL deficiency while Googling this morning. It seems MBL deficiency is considered an autoimmune disease and the last line of this information, his IvG 2/4 deficiency, says they are susceptible to autoimmune issues. Which came first; the chicken or the egg ?!?!?