New drug in Sclero Forums (MAIN) Posted May 14, 2009 · Report reply Hi, Birdman, it's good to hear from you. Sorry you are still having difficulties with your lungs. I know there are several people on the site who have had experience with Azathioprine (Imuran is one drug company's name for it). Hopefully they will share their experiences. Here is our page on Immunosuppressants which has a section on this drug: Azathioprine (Imuran). Patient Education. American College of Rheumatology. Twelve-month azathioprine as maintenance therapy in early diffuse systemic sclerosis patients treated for 1-year with low dose cyclophosphamide pulse therapy. This study suggests a role of AZA in maintaining the improvement induced by low dose pulse CYC in early dcSSc, making it possible a short duration of treatment at a low cumulative dose of the drug. These results, however, await confirmation in controlled studies. PubMed. Clin Exp Rheumatol. 2007 Jul-Aug;25(4):613-6. A randomized unblinded trial of cyclophosphamide CYC) versus azathioprine (AZ) in the treatment of systemic sclerosis. After treatment there was a statistically significant improvement in the modified Rodnan skin score, attack frequency of Raynaud's phenomenon, and erythrocyte sedimentation rate (ESR) in the CYC-group, but not in the AZ-group. PubMed. Clin Rheumatol. 2006 Mar;25(2):205-12. Epub 2005 Oct 14.