Update on morphea in Sclero Forums (MAIN) Posted June 9, 2011 Update on morphea: part I. Epidemiology, clinical presentation, and pathogenesis. The underlying pathogenesis of morphea is incompletely understood at this time, but ultimately results in an imbalance of collagen production and destruction. Fett N. J Am Acad Dermatol. 2011 Feb;64(2):217-28. (Also see: Morphea) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.