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Found 38 results

  1. Study of “Pre-Ulcer ” Stage May Inform Treatment of Digital Ulcers in Scleroderma. These findings can help develop strategies to prevent digital ulcers, such as avoiding severe cold, hand hygiene, and avoiding mechanical injury. Scleroderma News, 02/21/2020. (Also see Research on Digital Ulcers) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  2. A patient-centered approach to the burden of symptoms in patients with scleroderma treated with Bosentan: A prospective single-center observational study. Bosentan therapy may indirectly influence functionality and quality of life in patients with scleroderma by reducing the burden of Raynaud's and digital ulcer-related symptoms. PubMed, Exp Ther Med, 2020 Mar;19(3):1739-1746. (Also see Tracleer (Bosentan)) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  3. Digital ulcers (DUs) in systemic sclerosis: their epidemiology, clinical characteristics, and associated clinical and economic burden. DUs place a large burden on the patient and healthcare system through reduced health-related quality of life and increased healthcare resource utilization and associated cost. PubMed, Arthritis Res Ther, 2019 Dec 23;21(1):299. (Also see Digital Ulcers) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  4. LAUDES Study: impact of digital ulcers (DUs) on hand functional limitation, work productivity and daily activities, in systemic sclerosis (SSc) patients. Study findings show an impaired hand function and increased disability for daily life activities and work productivity in SSc patients with DUs compared with patients without DUs in Spanish population. PubMed, Rheumatol Int, 2019 Nov;39(11):1875-1882. (Also see Digital Ulcers) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  5. Peripheral blood eosinophilia is associated with the presence of skin ulcers in patients with systemic sclerosis (SSc). These results suggest that eosinophils are involved in the pathogenesis of vascular dysfunction of SSc. PubMed, J Dermatol, 02/04/2019. (Also see Digital Ulcers and Antibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  6. A randomised placebo–controlled double–blind trial to assess the safety of intramuscular administration of allogeneic mesenchymal stromal cells (MSCs) for digital ulcers (DUs) in systemic sclerosis (SSc). The Mesenchymal stromal cells for Angiogenesis and Neovascularization in digital Ulcers of Systemic Sclerosis (MANUS) Trial intended to assess the safety and potential efficacy of MSCs for DUs of SSc. PubMed, BMJ Open, 2018 Aug 20;8(8):e020479. (Also see Treatments for Digital Ulcers) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  7. A Feasibility Study of a Novel Low Level Light Therapy (LTTT) for Digital Ulcers (DUs) in Systemic Sclerosis. LTTT for DUs is safe, feasible and well tolerated. There was an early tentative suggestion of treatment efficacy. PubMed, J Dermatolog Treat, 2018 Jun 4:1-30. (Also see Treatments for Digital Ulcers) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  8. Should all digital ulcers (DUs) be included in future clinical trials of systemic sclerosis (SSc)–related digital vasculopathy? We would encourage the expert SSc community to reconsider the rationale for including only fingertip DUs in future SSc clinical trials, and suggest an agenda for future research. PubMed, Med Hypotheses, 2018 Jul;116:101-104. (Also see Research on Digital Ulcers) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  9. Hi, I have been a systemic sclerosis patient for over 12 years now. I am 31 years old. Along the way I developed several digital ulcers on my fingertips. However, for the first time in 12 years I have developed one such ulcer on the right big toe. It is on the corner where the nail meets the skin. It is very painful and uncomfortable. I cannot wear closed shoes because it is painful and if I wear open footwear, I am either stepped upon or I hit my foot into daily objects. Have any of you experienced ulcers on your feet? If yes, can you please tell me how you dealt with it and things you did to make it less painful . Thanks!
  10. Ultrasound (US) characterization of cutaneous ulcers in systemic sclerosis (SSc). US may support the assessment of morphology and extent of skin ulcers in SSc and can be a helpful tool for detecting underlying pathology. PubMed, Clin Rheumatol, 03/10/2018. (Also see Digital Ulcers) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  11. Doctors discover new method to heal painful diabetic ulcers using a jab of 'muffin top' fat. Doctors have discovered an ingenious use for the excess fat — they are using it in injections for painful foot ulcers that are difficult to treat. Mail Online, 12/02/2017. (Also see Treatments for Digital Ulcers and Treatments for Diabetes) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  12. Defining a unified vascular phenotype in systemic sclerosis. The more recent biomarker longitudinal studies support the concept of generalized vasculopathy and a potential association between various cardiovascular complications. PubMed, Arthritis Rheumatol, 11/16/2017. (Also see Vascular Involvement and Digital Ulcers) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  13. I am in so much pain with a digital ulcer. Developed about 2.5 months ago. The tissue has died. Can anyone suggest what I can do speed up healing process. Constant burning and painful. I had iloprost infusions but reacted badly to it.
  14. The critical need for accurately defining digital ulcers in scleroderma. The high unmet need for a standardized method of defining digital ulcers is a major challenge not only for treatment, but also for development of new therapies. Journal of Scleroderma and Related Disorders, JSRD 2017; 2(2): 69 - 71. (Also see Digital Ulcers) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  15. Reduced perfusion in systemic sclerosis digital ulcers (DUs) (both fingertip and extensor) can be increased by topical application of glyceryl trinitrate (GTN). DUs (both fingertip and extensor) were responsive to topical GTN, with an increase in perfusion to the ischaemic DU centre. PubMed, Microvasc Res, 2016 Dec 24;111:32-36. (Also see Treatments for Digital Ulcers: Topical) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  16. I hope some of you can give me helpful information. My brother has been diagnosed with several auto immune diseases. One of them is Raynauds. Right now his fingers are in a terrible condition: black, drainage from around the nail, sensitivity in the fingers, etc. They are a mess. He is wearing gloves, on several medications and is being seen by a rheumatologist. Do any of you have this type of condition with your fingers and to the extreme like his fingers. We are very concerned that he may lose some of his fingers by just the appearance. Any helpful comments in this area would be greatly appreciated. Thanks
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