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Found 115 results

  1. Older age onset of systemic sclerosis (SSc) - accelerated disease progression in all disease subsets. In this large registry, 25% of patients developed SSc at an age above 60 years with an increased frequency of limited cutaneous systemic sclerosis. PubMed, Rheumatology (Oxford), 04/24/2020. (Also see Causes of Scleroderma) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  2. Long-standing morphea and the risk of squamous cell carcinoma of the skin (cSCC). Fibrosis, inflammation and chronic ulcerations may eventually promote skin neoplasms; morphea is therefore a rare but established risk factor for cSCC. PubMed, J Dtsch Dermatol Ges, 05/04/2020. (Also see Causes of Morphea) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  3. Systemic Sclerosis and Vaccinations. Age over 65 years old, interstitial lung disease, and ongoing immunosuppressive therapy were significantly related with acceptance to both vaccinations using univariate analyses. PubMed, Vaccines (Basel), 2020 Apr 28;8(2). (Also see Vaccinations) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  4. Effect of a tailored home-based exercise program in patients with Systemic Sclerosis (SSc): a randomized controlled trial. This study indicates that in SSc patients a minimally supervised, home-based exercise program improves physical performance, quality of life and disability in comparison to usual care. PubMed, Scand J Med Sci Sports, 04/29/2020. (Also see Coping Strategies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  5. Comparative analysis of affected and unaffected areas of systemic sclerosis (SSc) skin biopsies by high-throughput proteomic approaches. We identified a number of proteins and pathways that might be involved in SSc progression and pathogenesis. PubMed, Arthritis Res Ther, 2020 May 7;22(1):107. (Also see Skin Fibrosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  6. Silica Exposure and Scleroderma: More Bridges and Collaboration between Disciplines Are Needed. The lack of a proper understanding of the pathogenesis of silica-associated autoimmunity may also result from missing bridges between disciplines. PMC, Am J Respir Crit Care Med, 2020 Apr 1; 201(7): 880–882. (Also see Silica Exposure) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  7. Antigen-specific (Ab) humoral responses against Helicobacter pylori (Hp) in patients with systemic sclerosis (SSc). Anti-Hp Abs are neither more frequent nor elevated in SSc compared with healthy population and these results suggest that Hp is unlikely to be involved in the development of SSc. PubMed, Immunol Res, 04/06/2020. (Also see Antibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  8. Case Report: COVID-19 in a patient with systemic sclerosis (SSc) treated with tocilizumab for Ssc-interstitial lung disease (ILD.) Our case indicates that IL-6-blocking treatment given for chronic autoimmune diseases may even prevent the development of severe COVID-19. BMJ Journals, Ann rheumatologist Dis. (Also see Clinical Trials) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  9. Characteristics of Pulmonary Arterial Hypertension in Patients with Systemic Sclerosis and Anticentriole Autoantibodies (ACA). ACA-positive SSc-PAH rapidly deteriorates, so careful hemodynamic observation and timely aggressive use of pulmonary vasodilators should be considered. PubMed, Int Heart J, 2020;61(2):413-418. (Also see Antibodies and Pulmonary Hypertension Symptoms and Complications) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  10. Biphasic Temporal Relationship between Cancers and Systemic Sclerosis (SSc): A Clinical Series from Montpellier University Hospital and Review of the Literature. This study brought to light two peaks of cancer occurrence in SSc patients. PubMed, J Clin Med, 2020 Mar 20;9(3). (Also see Cancer) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  11. Kelch-like protein 42 is a pro-fibrotic ubiquitin E3 ligase involved in in systemic sclerosis (SSc). Our findings indicate that the KLHL42-PPP2R5e axis controls pro-fibrotic signaling in SSc lung fibroblasts. PubMed, J Biol Chem, 02/17/2020. (Also see Fibroblasts) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  12. Early trajectories of skin thickening are associated with severity and mortality in systemic sclerosis (SSc). Early identification of clinical phenotype based on skin thickening trajectories could predict morbi-mortality in SSc. PubMed, Arthritis Res Ther, 2020 Feb 18;22(1):30. (Also see Skin Fibrosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  13. Study of “Pre-Ulcer ” Stage May Inform Treatment of Digital Ulcers in Scleroderma. These findings can help develop strategies to prevent digital ulcers, such as avoiding severe cold, hand hygiene, and avoiding mechanical injury. Scleroderma News, 02/21/2020. (Also see Research on Digital Ulcers) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  14. A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis (SSc) and Crohn's disease (CD). Through the first cross-disease meta-analysis of SSc and CD, we identified genetic variants with pleiotropic effects on two clinically distinct immune-mediated disorders. PubMed, Sci Rep. 2020 Feb 5;10(1):1862. (Also see Inflammatory Bowel Disease) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  15. Hi Ron here, how are you coping with the pandemic? I am in Calgary Alberta Canada, it starting to get bad here, everyone is urged stay home and a pile of non essential business, inc doctor offices are closed. Going shopping is a nightmare, people hoarding, shortages long line ups to get in stores, I think its going to get a lot worse. I am not afraid of the virus, I will respect it, but I will not let it control my life. I have poor lung function, due to pulmonary fibrosis, from SD, but I am not afraid of the virus. My mom is 78 and us boys will do her shopping for her, to limit her risk.
  16. Information About COVID-19 for Scleroderma Patients. Patients with scleroderma should take extra precautions to minimize the risk of getting COVID-19. Scleroderma News, 03/19/2020. This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  17. Impaired Swallowing Linked to Depression, Lower Quality of Life in Scleroderma, Study Finds. Swallowing trouble in people with scleroderma is associated with lower quality of life and a higher incidence of depression, a study found. Scleroderma News, 02/05/2020. (Also see Dysphagia and Depression) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  18. Regulation of skin fibrosis by RALDH1-producing dermal dendritic cells (DCs) via retinoic acid-mediated regulatory T cell induction: A role in scleroderma (SSc). This study identified a critical role of dermal DCs as a regulator of Treg development through RALDH1 in bleomycin-treated mice and possibly in human SSc. PubMed, J Dermatol Sci, 01/15/2020. (Also see Dendritic Cells) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  19. Digital ulcers (DUs) in systemic sclerosis: their epidemiology, clinical characteristics, and associated clinical and economic burden. DUs place a large burden on the patient and healthcare system through reduced health-related quality of life and increased healthcare resource utilization and associated cost. PubMed, Arthritis Res Ther, 2019 Dec 23;21(1):299. (Also see Digital Ulcers) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  20. Analysis of gene expression profiles and protein-protein interaction networks in multiple tissues of systemic sclerosis (SSc). Analysis indicated that there were common pathological clusters that contributed to the pathogenesis of SSc in different tissues. PubMed, BMC Med Genomics, 2019 Dec 27;12(1):199. (Also see Cluster Studies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  21. Electrocardiographic markers for the prediction of ventricular arrhythmias in patients with systemic sclerosis. The question is whether certain ECG parameters reflecting ventricular repolarization may help to recognize scleroderma patients with increased risk for ventricular arrhythmias and sudden cardiac death. PubMed, Rheumatology (Oxford), 01/14/2020. (Also see Complications with Heart Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  22. Characterizing Disease Manifestations and Treatment Patterns Among Adults with Systemic Sclerosis (SSc): A Retrospective Analysis of a US Healthcare Claims Population. One-third of patients with SSc in the healthcare claims population received immunomodulating therapy during the first year after diagnosis. PubMed, Rheumatol Ther, 11/16/2019. (Also see Immunosuppressants) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  23. Advances in the Treatment of Scleroderma (SSc): Autologous Hematopoietic Stem Cell Transplant (HSCT). HSCT can be considered as an option in carefully selected patients with rapidly progressive SSc who have a risk of organ failure. Medscape, 1/2/2020. (Also see Stem Cell Transplantation) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  24. Dipeptidylpeptidase 4 as a Marker of Activated Fibroblasts and a Potential Target for the Treatment of Fibrosis in Systemic Sclerosis (SSc). DPP-4 characterizes a population of activated fibroblasts and shows that DPP-4 regulates TGFβ-induced fibroblast activation in the fibrotic skin of SSc patients. PubMed, Arthritis Rheumatol, 2020 Jan;72(1):137-149. (Also see Fibroblasts) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  25. I have sore hands this year more than other years. My scleroderma is hitting me hard and it has been cold and stormy here. My rheumatologist suggested I put a thick layer of lotion on my hands, put on cotton gloves when I go to bed and all the lotion will be absorbed. It is doing the trick; my hands look much better and not as painful. I had a sore that he thought might turn into an ulcer and it is now gone away. I hope this can help others. I wear the gloves doing my daily routine and I am glad I gave it a try. Blessings to all.
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