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Colonic and Anorectal Manifestations of Systemic Sclerosis. Colonic and anorectal manifestations of systemic sclerosis include constipation, diarrhea, and fecal incontinence, and can diminish quality of life for these patients. PubMed, Curr Gastroenterol Rep, 2019 Jul 8;21(7):33. (Also see Bowel Dysfunction) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.