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Found 24 results

  1. Scleroderma-specific autoantibodies embedded in immune complexes (ICs) mediate endothelial damage: an early event in the pathogenesis of systemic sclerosis. These data provide the first demonstration of the pathogenicity of ICs from scleroderma patients with different autoantibodies on the endothelium. PubMed, Arthritis Res Ther, 2020 Nov 9;22(1):265. (Also see Antibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  2. Putative functional pathogenic autoantibodies in systemic sclerosis. Several novel interesting autoantibodies, targeting antigens within the extracellular matrix or on the cell surface have been recently described in patients with SSc. PubMed, Eur J Rheumatol, 2020 Oct;7(Suppl 3):S181-S186. (Also see Antibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  3. Evaluation of Malignancy Risk in Scleroderma (SSc) by Antibody Profile. A close temporal relationship between onset of SSc and malignancy has been reported in patients with anti-RNA polymerase III antibody. PubMed, Br J Dermatol, 09/13/2020. (Also see Cancer) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  4. Prevalence of antiphospholipid antibodies in patients with overt myocardial dysfunction in systemic lupus erythematosus. A case-control study. This study did not find any significant association of anti-phospholipid antibodies with overt myocardial dysfunction in patients of SLE. PubMed, Lupus, 2020 Aug 4;961203320947784. (Also see Symptoms and Complications of Lupus and Antiphospholipid Syndrome) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  5. You May Have Antibodies After Coronavirus Infection, But Not for Long. Antibodies to the virus faded quickly in asymptomatic people, scientists reported. That does not mean immunity disappears. New York Times, 06/20/2020. (Also see Antibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  6. What can coronavirus antibody tests actually tell us? Assuming that positive antibody test results confer immunity is a "very dangerous conclusion," say experts. NBC Health News, 04/21/2020. (Also see Autoantibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  7. Antigen-specific (Ab) humoral responses against Helicobacter pylori (Hp) in patients with systemic sclerosis (SSc). Anti-Hp Abs are neither more frequent nor elevated in SSc compared with healthy population and these results suggest that Hp is unlikely to be involved in the development of SSc. PubMed, Immunol Res, 04/06/2020. (Also see Antibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  8. Smoking and systemic sclerosis (SSc): influence on microangiopathy and expression of anti-topoisomerase I antibodies (ATA) in a monocentric cohort. We observed a significant association between smoking history and positivity of ATA and we outlined the idea of a different effect of smoking on autoantibody expression between men and women. PubMed, Clin Exp Rheumatol, 03/25/2020. (Also see Antibodies and Preventive Care for Pulmonary Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  9. Characteristics of Pulmonary Arterial Hypertension in Patients with Systemic Sclerosis and Anticentriole Autoantibodies (ACA). ACA-positive SSc-PAH rapidly deteriorates, so careful hemodynamic observation and timely aggressive use of pulmonary vasodilators should be considered. PubMed, Int Heart J, 2020;61(2):413-418. (Also see Antibodies and Pulmonary Hypertension Symptoms and Complications) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  10. A comprehensive analysis of antigen-specific antibody responses against human cytomegalovirus (HCMV) in patients with systemic sclerosis (SSc). More prevalent and/or stronger antigen-specific HCMV responses are noted in SSc compared to controls, implying a role of these viral responses in SSc development. PubMed, Clin Immunol, 07/29/2019. (Also see Antibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  11. Clinical Manifestation and Incidence of Cardiopulmonary Complications in Early Systemic Sclerosis (SSc) Patients with Different Antibody Profiles. It was found that the presence of SSc-specific autoantibodies was associated with a distinctive clinical presentation and cumulative internal organ involvement, even in the early phase of the disease. PubMed, J Clin Med Res, 2019 Jul;11(7):524-531. (Also see Antibodies and Research about Scleroderma Cardiac (Heart) Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderm
  12. Antibodies against specific extractable nuclear antigens (ENAs) as diagnostic and prognostic tools and inducers of a profibrotic phenotype in cultured human skin fibroblasts: are they functional? This study suggests a pathogenic role of scleroderma-specific autoantibodies to directly induce pro-fibrotic activation in human dermal fibroblasts. PubMed, Arthritis Res Ther, 2019 Jun 24;21(1):152. (Also see Fibroblasts and Antibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  13. Differential synovial tissue (ST) biomarkers among psoriatic arthritis and rheumatoid factor/anti–citrulline antibody–negative rheumatoid arthritis. Histological analysis of ST may help to solve the clinical overlap between the two diseases and provides prognostic data about the therapy success. PubMed, Arthritis Res Ther, 2019 May 9;21(1):116. (Also see Diagnosis of Rheumatoid Arthritis and Psoriasis and Psoriatic Arthritis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  14. Peripheral blood eosinophilia is associated with the presence of skin ulcers in patients with systemic sclerosis (SSc). These results suggest that eosinophils are involved in the pathogenesis of vascular dysfunction of SSc. PubMed, J Dermatol, 02/04/2019. (Also see Digital Ulcers and Antibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  15. Can you help me interpret these results? I'm so confused what all this means. Obviously I have some type of autoimmune disease going on, I'm guessing omment: A positive ANA result may occur in healthy individuals (low titer) or be associated with a variety of diseases. See interpretation chart which is not all inclusive: Pattern Antigen Detected Suggested Disease Association ----------- ---------------- ----------------------------- Homogeneous DNA(ds,ss), SLE - High titers Nucleosomes, Histones Drug-induced SLE ----------- ---------------- ----------------------------- Speckled Sm
  16. Antinuclear Antibodies in Systemic Sclerosis: an Update. Autoantibodies specific for systemic sclerosis have been linked to distinct clinical features, so therefore, detecting a particular antibody type is important in predicting a possible organ involvement and prognosis. PubMed, Clin Rev Allergy Immunol, 01/03/2019. (Also see Antibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  17. The relationship between type 1 IFN and vasculopathy in anti-MDA5 antibody–positive dermatomyositis (DM) patients. The high T1-IFN signatures of the MDA5 antibody–positive DM patients in serum and deep vasculatures suggested that T1-IFN may have important roles in the vasculopathy of these patients. PubMed, Rheumatology (Oxford), 12/11/2018. (Also see Dermatomyositis and Polymyositis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  18. Just a gentle request to our forum members (especially new ones). The subject of positive blood tests is a very popular topic on the Forums and so I would politely suggest that before posting a similar query all forum members read the post below to see if it covers your situation. As we do have an inordinate amount of almost identical threads about blood tests and positive antibodies, I thought I would reiterate the advice we always give about positive blood tests; although they help in the diagnostic process, they are by no means the be all and end all of a diagnosis,
  19. Anti-RNPC3 (U11/U12) antibodies in systemic sclerosis are associated with moderate to severe gastrointestinal dysmotility. After adjusting for relevant covariates and potential confounders, moderate to severe GI disease was associated with anti-RNPC3 antibodies. PubMed, Arthritis Care Res (Hoboken), 09/22/2018. (Also see Antibodies and Dysmotility) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  20. Prevalence of auto–antibodies associated to pulmonary arterial hypertension in scleroderma – A review. The available evidence points in the direction of a strong association between auto–immune mechanisms and pulmonary hypertension in the setting of scleroderma. PubMed, Autoimmun Rev, 10/11/2018. (Also see Pulmonary Hypertension and Antibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  21. Immune complexes (ICs) containing scleroderma (SSc)–specific autoantibodies induce a profibrotic and proinflammatory phenotype in skin fibroblasts. These data provide the first demonstration of the proinflammatory and profibrotic effects of SSc–ICs on fibroblasts, suggesting the potential pathogenicity of SSc autoantibodies. PubMed, Arthritis Res Ther, 2018 Aug 29;20(1):187. (Also see Fibroblasts and Antibodies in Systemic Scleroderma) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  22. Antibodies to aquaporins (AQPs) are frequent in patients with primary Sjögren’s syndrome (SS). Antibodies to AQPs (especially to AQP8 and AQP9) are frequent in SS patients and the likely important role of AQPs in salivary gland secretions justifies further research. Rheumatology, 08/31/2017. (Also see Diagnosis of Sjögren's Syndrome) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  23. Anti–endothelial cell antibodies (AECA) do not correlate with disease activity in systemic sclerosis (Ssc). AECA are not associated with the activity of SSc, although the presence of AECA might be an indicator of vascular complications development in Ssc. PubMed, Postepy Dermatol Alergol, 2018 Apr;35(2):185-191. (Also see Antibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  24. The Scleroderma Education Project SclerodermaInfo.org article "Scleroderma ANA and Antibody Testing Basics" has been updated. It is one of four articles in the "ANA and Antibody Series". (Also see Scleroderma Webmaster's Association and Antibodies Posted 03/19/2017. This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
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