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The role of epigenetics and immunological imbalance in the etiopathogenesis of psoriasis (Ps) and psoriatic arthritis (PsA). Besides well-known genetic susceptibility loci, epigenetic DNA modifications, which are associated with Ps development, have been characterized recently. PubMed, Ther Adv Musculoskelet Dis, 2019 Nov 6;11:1759720X19886505. (Also see Psoriasis and Psoriatic Arthritis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

The interaction between environmental triggers and epigenetics in autoimmunity. Reactive oxygen species that inhibit Dnmt1 upregulation, and a diet poor in methyl donors, combine to cause lupus in animal models. PubMed, Clin Immunol, 04/09/2018. (Also see Causes of Lupus) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.