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Quantifying the Effect of Diabetes on Surgical Hand and Forearm Infections. Diabetes exacerbates the burden of surgical upper–extremity infections and higher risk for amputation. PubMed, J Hand Surg Am, 12/11/2017. (Also see Symptoms and Complications of Diabetes) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.