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Association between leptin and IL-6 concentrations with cardiovascular risk (CVR) in patients with rheumatoid arthritis. There is a positive association between CVR and serum leptin concentrations and it is also significantly associated with traditional and non–traditional risk factors. PubMed, Clin Rheumatol, 11/03/2017. (Also see Symptoms and Complications of Rheumatoid Arthritis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.