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Found 14 results

  1. Unmet needs in patients with moderate-to-severe plaque psoriasis treated with methotrexate (MTX) in real world practice: FirST study. The study identified unmet needs in moderate-to-severe plaque psoriasis patients treated with MTX. PubMed, J Dermatolog Treat, 2020 Sep 8;1-10. (Also see Psoriasis and Psoriatic Arthritis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  2. Case Report: Etiologic role of Borrelia burgdorferi in morphea. After diagnosis of morphea was established, and with systemic therapy (corticosteroids and methotrexate), the evolution was favorable. PubMed, Exp Ther Med. (Also see Causes of Morphea) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  3. Long-Term Efficacy of Methotrexate Demonstrated in Pediatric Linear Scleroderma. Patients treated with methotrexate (MTX) for pediatric linear scleroderma may achieve complete and long-lasting remission. Rheumatology Advisor, 06/22/2020. (Also see Juvenile Scleroderma and Juvenile Scleroderma Research) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  4. Effect of Methotrexate Use on the Development of Type 2 Diabetes in Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis. Rheumatoid arthritis patients on methotrexate treatment had a lower risk of developing type 2 diabetes compared to rheumatoid arthritis patients not exposed to methotrexate. PubMed, PLoS One, 2020 Jul 6;15(7):e0235637. (Also see Symptoms and Complications of Rheumatoid Arthritis and Immunosuppressants) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  5. Metabolic Syndrome and Female Gender, but Not Methotrexate, Are the Important Associations of Significant Liver Fibrosis in Patients With Moderate-To-Severe Psoriasis as Detected by Transient Elastography. Metabolic syndrome and female sex are associated with the development of significant liver fibrosis in patients with psoriasis. PubMed, Indian J Dermatol Venereol Leprol, 07/08/2020. (Also see Psoriasis and Psoriatic Arthritis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  6. Treatment With Mycophenolate (MMF) and Cyclophosphamide (CYC) Leads to Clinically Meaningful Improvements in Patient-Reported Outcomes in Scleroderma Lung Disease (SSc-ILD). Treatment with CYC and MMF improved overall health-related quality of life in patients with SSc-ILD. PubMed, ACR Open Rheumatol, 05/20/2020. (Also see Cellcept and Cyclophosphamide) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  7. Type 2 Polarized T Cell Phenotype is Associated with Methotrexate (MTX) Non-response in Patients with Rheumatoid Arthritis (RA). MTX-non-responsive RA patients exhibit a bias towards type 2-polarized T cell inflammatory responses. PubMed, Arthritis Rheumatol, 02/10/2020. (Also see Diagnosis of Rheumatoid Arthritis, Immunosuppressants and B Cells and T Cells) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  8. Case Report: Eosinophilic Fasciitis Responds Well to Steroids and Methotrexate. There was an excellent response to steroids and methotrexate, which is not a combination therapy that has been tried or mentioned previously. PubMed, Oman Med J, 2019 Nov;34(6):564-567. (Also see Eosinophilic Fasciitis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  9. Hi! I’m Amber 33 and new to the forum. My symptoms started with numbness and tingling in my hands and arms along with extreme stiffness and weakness in my hands. My doctors thought it was carpal tunnel but it didn’t make sense seeing how I had been a stay at home mom for ten years prior. Afterwards, my hands began to swell, my hip started becoming sore, I had this strange bruise type rash that wouldn’t go away down my leg, and my shoulders began keeping me up at night. My mother passed with leukemia around this time and things got even worse. My neck would pain me constantly and fe
  10. Hi all I have generalised morphea undiagnosed for 4 months. All over front, most of back, legs and arms. Started methotrexate (MTX) two weeks ago - test dose 2.5 then 2 doses of 15mg each with a 5mg folic acid two days after. Feeling very tired, nauseous. This weekend particularly tired and nauseous. This morning - 3 days after MTX developed a sore in the corner of my mouth. Rang registrar as per instructions on the MTX leaflet. She said stop taking it until I'm seen in clinic. I said that I had read that many people seem to need more folic acid when on MTX. She said as I've reacted so s
  11. Hi, I was diagnosed with localised scleroderma back in 2010. I started with one large patch at the very top on the back of my leg. 5 years on I now have 2 larger plaques and 4 smaller plaques. Based in the UK, I was referred to a specialist a few years ago and since then I've tried the steroid creams, PUVA light treatment and now I am on methotrexate. At 22 years of age, I don't really want to be taking methotrexate but I felt I had no other options. I want to know if anybody else has found methotrexate works for them? I am on 10mg (4 x 2.5 tabs each week) and take folic acid every ot
  12. Hi there, Since starting Methotrexate 8 weeks ago my C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels have been rising. They are now doubled and CRP is now 85. My general practitioner and rheumatologist have both phoned me about it. I am having another blood test tomorrow and then rheumatologist will decide whether or not I stay on it. I was quite surprised when I heard how high it was as joint pain has eased a lot in the last month. I have developed a cough that I can't get rid of and my fatigue has increased. Has anyone else had a similar experience?
  13. Hey everyone - I have started my 2nd week of methotrexate therapy at 5mg. It bumps to 15 mg next week and I am very anxious. With the low dose I have noticed quite a range of side effects. The first weekend all I did was sleep! Extreme fatigue, headache, and swollen lymph nodes (my blood work came back good). The second week, less fatigue but quite a headache, swollen nodes, shakiness, dizziness, chest discomfort, light cough, heart racing feeling, weakness. I have also noted some water retention (my hands swelled up really large). I am taking folic acid and multivitamins daily.
  14. Just diagnosed with scleroderma, most likely systemic. Waiting for more test results. My doctor has given me a prescription for Methotrexate. He said he does not know if it will help me or hurt me and that it is my decision. What? Really? I don't know what to do, I am so scared. Please tell me your stories on this medication.
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