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A randomised placebo–controlled double–blind trial to assess the safety of intramuscular administration of allogeneic mesenchymal stromal cells (MSCs) for digital ulcers (DUs) in systemic sclerosis (SSc). The Mesenchymal stromal cells for Angiogenesis and Neovascularization in digital Ulcers of Systemic Sclerosis (MANUS) Trial intended to assess the safety and potential efficacy of MSCs for DUs of SSc. PubMed, BMJ Open, 2018 Aug 20;8(8):e020479. (Also see Treatments for Digital Ulcers) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.