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Predictors of disease activity and structural progression after treatment with adalimumab plus methotrexate or continued methotrexate monotherapy in patients with early rheumatoid arthritis. Findings suggested a relationship between the addition of adalimumab at 6 months after methotrexate failure and improved outcomes. PubMed, Ann rheumatologist Dis, 08/03/2018. (Also see Treatments for Rheumatoid Arthritis and Immunosuppressants) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
Hi all I have generalised morphea undiagnosed for 4 months. All over front, most of back, legs and arms. Started methotrexate (MTX) two weeks ago - test dose 2.5 then 2 doses of 15mg each with a 5mg folic acid two days after. Feeling very tired, nauseous. This weekend particularly tired and nauseous. This morning - 3 days after MTX developed a sore in the corner of my mouth. Rang registrar as per instructions on the MTX leaflet. She said stop taking it until I'm seen in clinic. I said that I had read that many people seem to need more folic acid when on MTX. She said as I've reacted so soon don't take it because I would then have to be admitted to be given folic infusions? Does this make any sense to anyone? I'm the first case that the registrar has treated and she's having to ask the consultant for answers for all my questions - am I wrong to feel worried?
Oral to subcutaneous (SC) methotrexate (MTX) dose–conversion strategy in the treatment of rheumatoid arthritis. SC administration provided higher exposure of MTX than the same dose given orally. PubMed, Rheumatol Int, 12/23/2016. (Also see Treatments for Rheumatoid Arthritis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
Hey everyone - I have started my 2nd week of methotrexate therapy at 5mg. It bumps to 15 mg next week and I am very anxious. With the low dose I have noticed quite a range of side effects. The first weekend all I did was sleep! Extreme fatigue, headache, and swollen lymph nodes (my blood work came back good). The second week, less fatigue but quite a headache, swollen nodes, shakiness, dizziness, chest discomfort, light cough, heart racing feeling, weakness. I have also noted some water retention (my hands swelled up really large). I am taking folic acid and multivitamins daily. I extremely worried about my dose tripling this next week-particularly the hair loss. I was just wondering what other people have experienced with this therapy? Did you have similiar side effects? Did you lose a lot of hair (ie: some, handfuls, bald?) All-in-all I have noticed its helped my morphea and LS - I also do not have the debilitating chronic pain everyday that I previously had. Thanks!