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Found 7 results

  1. Increased expression of GAB1 promotes inflammation and fibrosis in systemic sclerosis (SSc). This data suggests that GAB1 has a relatively high expression rate in SSc, and knockdown of GAB1 may attenuate SSc by stimulating inflammatory and fibrotic processes. PubMed, Exp Dermatol, 09/10/2019. (Also see Prognosis and Mortality and Skin Fibrosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  2. Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis (dSSc): a European Scleroderma Trials and Research (EUSTAR) analysis. The use of the predictive factors presented here could enable cohort enrichment with patients at risk for overall disease worsening in SSc clinical trials. PubMed, Ann rheumatologist Dis, 06/21/2019. (Also see Diffuse Scleroderma) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  3. Prediction of progression of interstitial lung disease (ILD) in patients with systemic sclerosis (SSc): the SPAR model. The evidence–based SPAR prediction model developed in our study might be helpful for the risk stratification of patients with mild SSc–ILD in clinical practice and cohort enrichment for future clinical trial design. PubMed, Ann rheumatologist Dis, 06/06/2018. (Also see Severity and Prognosis for Scleroderma Pulmonary Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  4. First clinical symptom as a prognostic factor in systemic sclerosis: results of a retrospective nationwide cohort study. The mode of onset should be considered an independent prognostic factor in systemic sclerosis and, in particular, patients who initially present with non–Raynaud's phenomenon may be considered of poor prognosis. PubMed, Clin Rheumatol, 12/07/2017. (Also see Prognosis and Mortality) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  5. Potential biomarkers in patients with systemic sclerosis (SSc). Endostatin, elastase and the soluble adhesion molecules (sICAM-1 and sVCAM-1) are potentially involved in the pathogenesis of SSc. PubMed, Int J rheumatologist Dis, 10/11/2017. (Also see Prognosis and Mortality) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  6. The role of microRNA-5196 in the pathogenesis of systemic sclerosis (SSc). These results suggest that microRNA-5196 can be used as a potential biomarker characterising SSc. PubMed, Eur J Clin Invest, 06/21/2017. (Also see Prognosis and Mortality) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  7. Early mortality in a multinational systemic sclerosis (SSc) inception cohort. Early mortality in SSc is substantial and prevalent cohorts underestimate mortality in SSc by failing to capture early deaths, particularly in men and those with diffuse disease. PubMed, Arthritis Rheumatol, 12/28/2016. (Also see Prognosis and Mortality) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
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