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Type 2 Polarized T Cell Phenotype is Associated with Methotrexate (MTX) Non-response in Patients with Rheumatoid Arthritis (RA). MTX-non-responsive RA patients exhibit a bias towards type 2-polarized T cell inflammatory responses. PubMed, Arthritis Rheumatol, 02/10/2020. (Also see Diagnosis of Rheumatoid Arthritis, Immunosuppressants and B Cells and T Cells) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

Differential synovial tissue (ST) biomarkers among psoriatic arthritis and rheumatoid factor/anti–citrulline antibody–negative rheumatoid arthritis. Histological analysis of ST may help to solve the clinical overlap between the two diseases and provides prognostic data about the therapy success. PubMed, Arthritis Res Ther, 2019 May 9;21(1):116. (Also see Diagnosis of Rheumatoid Arthritis and Psoriasis and Psoriatic Arthritis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

T cell receptor β repertoires (TCR) as novel diagnostic markers for systemic lupus erythematosus and rheumatoid arthritis. These characteristics of the TCR repertoire can potentially serve as biomarkers and provide novel insights for disease status and therapeutical targets in autoimmune diseases. PubMed, Ann rheumatologist Dis, 05/17/2019. (Also see Diagnosis of Lupus and Diagnosis of Rheumatoid Arthritis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

Effects of Vitamin D on disease activity and serum interleukin-6 in rheumatoid arthritis (RA). This study suggests that vitamin D is not associated with disease activity or serum IL-6 levels but it may have a role in functional disability in RA patients. PubMed, Int J rheumatologist Dis, 02/06/2019. (Also see Diagnosis of Rheumatoid Arthritis and Vitamin D) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

Triple Positivity for Anti–Citrullinated Protein Autoantibodies (ACPAs), Rheumatoid Factor (RF), and Anti–Carbamylated Protein Antibodies (anti–carP) Conferring High Specificity for Rheumatoid Arthritis (RA): Implications for Very Early Identification of At–Risk Individuals. An autoantibody profile of triple positivity for ACPAs, RF and anti–CarP provides interesting information that might help identify individuals at risk of developing RA. PubMed, Arthritis Rheumatol, 2018 Nov;70(11):1721-1731. (Also see Diagnosis of Rheumatoid Arthritis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

Association between anti–citrullinated fibrinogen antibodies and coronary artery disease (CAD) in rheumatoid arthritis (RA). Anti–cit–fibrinogen antibodies as a group were associated with CAD outcomes in our RA cohort, with the strongest signal for association arising from a subset of the autoantibodies. PubMed, Arthritis Care Res (Hoboken), 10/08/2017. (Also see Diagnosis of Rheumatoid Arthritis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

Circulating osteoprotegerin levels are elevated in rheumatoid arthritis (RA): a systematic review and meta–analysis. Our meta–analysis revealed a significantly higher circulating osteoprotegerin level in RA patients, and it was influenced by race, disease duration, body mass index and disease activity score based on the assessment of 28 joints. PubMed, Clin Rheumatol, 07/11/2017. (Also see Diagnosis of Rheumatoid Arthritis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

Autoimmunity as a trigger for structural bone damage in rheumatoid arthritis. At present, rheumatoid factor and antibodies recognizing citrullinated proteins are considered as potent osteoclast inducers and triggers for bone loss in arthritis. PubMed, Mod Rheumatol, 2017 Jan 9:1-5. (Also see Diagnosis of Rheumatoid Arthritis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

The role of ultrasound in diagnosing rheumatoid arthritis, what do we know? An updated review. The use of musculoskeletal ultrasound adds value in diagnosing early RA, especially in seronegative arthritis. PubMed, Rheumatol Int, 11/01/2016. (Also see Diagnosis of Rheumatoid Arthritis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.