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  1. Increased expression of interferon regulated and antiviral response genes in CD31+/CD102+ lung microvascular endothelial cells from systemic sclerosis patients with end-stage interstitial lung disease. These observations suggest that interferon-induced and antiviral response proteins may participate in the pathogenesis of SSc vasculopathy and SSc-ILD. PubMed, Clin Exp Rheumatol, 11/17/2020. (Also see Pulmonary Fibrosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  2. Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4 + and CD8 + T-cell clusters in systemic sclerosis. Our results show that CD4+ and CD8+ T-cells are highly persistent in SSc patients over time, and this persistence is likely a result from antigenic selection. PubMed, J Autoimmun, 2020 Dec 8;117:102574. (Also see B Cells and T Cells) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  3. Case Report: Primary central nervous system lymphoma in scleroderma. We hypothesize that removing immunosuppression could allow the immune system to generate an inflammatory response to an underlying tumor or viral antigen. Journal of Scleroderma and Related Disorders. (Also see Cancer) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  4. Cancer and scleroderma (SSc): recent insights. The knowledge will allow the development of future prospective studies evaluating clinically relevant and targeted cancer screening strategies for newly diagnosed SSc patients. PubMed, Curr Opin Rheumatol, 2020 Nov;32(6):479-487. (Also see Cancer and Scleroderma) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  5. Bronchoalveolar Lavage (BAL) in Systemic Sclerosis (SSC) Patients: a Systematic Review. Alveolitis and the increase of some cytokines/chemokines in BAL were related to more severe pulmonary disease in SSc in the majority of the studies. PubMed, Curr Rheumatol Rev, 11/12/2020. (Also see Diagnosis of Pulmonary Involvement and Induced Sputum and Bronchoalveolar Lavage Tests) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  6. Nutritional status and predictors of weight loss in patients with systemic sclerosis (SSc). Nutritional risk and gastrointestinal involvement are frequent and closely correlated in patients with SSc. PubMed, Clin Nutr ESPEN, 2020 Dec;40:164-170. (Also see Gastrointestinal Involvement and Diet and Systemic Scleroderma) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  7. Scleroderma-specific autoantibodies embedded in immune complexes (ICs) mediate endothelial damage: an early event in the pathogenesis of systemic sclerosis. These data provide the first demonstration of the pathogenicity of ICs from scleroderma patients with different autoantibodies on the endothelium. PubMed, Arthritis Res Ther, 2020 Nov 9;22(1):265. (Also see Antibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  8. Putative functional pathogenic autoantibodies in systemic sclerosis. Several novel interesting autoantibodies, targeting antigens within the extracellular matrix or on the cell surface have been recently described in patients with SSc. PubMed, Eur J Rheumatol, 2020 Oct;7(Suppl 3):S181-S186. (Also see Antibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  9. Hi. I am newly diagnosed with Scleroderma. I was also recently diagnosed with Barrett’s, esphogitus and chronic gastritis in addition to immunoglobulin deficiency. Four years ago I was diagnosed with MS. My neurologist and rheumatologist both think I would benefit from IVIG especially given my leg pain/weakness, my gastrointestinal issues and my immunoglobulin deficiency. I am wondering for if anyone has any success getting IVIG approved for Scleroderma. Insurance doesn’t want to approve it for MS or my immunoglobulin disorder. I have lost a lot of weight. Can barely
  10. Evaluation of Malignancy Risk in Scleroderma (SSc) by Antibody Profile. A close temporal relationship between onset of SSc and malignancy has been reported in patients with anti-RNA polymerase III antibody. PubMed, Br J Dermatol, 09/13/2020. (Also see Cancer) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  11. Fatigue and its relationship with disease-related factors in patients with systemic sclerosis (SSc): a cross-sectional study. We recommend multidisciplinary approaches to evaluate and improve these parameters in the treatment of fatigue from the early period in SSc patients. PubMed, Turk J Med Sci, 09/15/2020. (Also see Fatigue) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  12. Undifferentiated connective tissue disease at risk for systemic sclerosis (SSC): Which patients might be labeled prescleroderma? Predicting at onset which patients with Raynaud’s phenomenon are going to develop SSc over time has long been a research objective and still is an unaccomplished task. PubMed, Autoimmun Rev, 2020 Sep 14;102659. (Also see Undifferentiated Connective Tissue Disease) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  13. Changes in mental health symptoms from pre-COVID-19 to COVID-19 among participants with systemic sclerosis from four countries: A scleroderma patient-centered intervention network (SPIN) cohort study. Anxiety symptoms, but not depression symptoms, increased dramatically during COVID-19 among people with a pre-existing medical condition. Journal of Psychosomatic Research, 10/03/2020. (Also see Anxiety and Attitude) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  14. Case Report: Hypertensive Emergency in a Woman with Systemic Sclerosis. We present a clinical case of scleroderma renal crisis with a typical presentation of hypertensive emergency and acute kidney injury. PubMed, High Blood Press Cardiovasc Prev, 10/01/2020. (Also see Kidney (Renal) Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  15. Frontiers in translational systemic sclerosis (SSc) research: a focus on the unmet 'cutaneous' clinical needs (Viewpoint). This viewpoint considers four cutaneous unmet clinical needs of patients with Ssc, which cause pain, disability, and/or disfigurement, all impact on quality of life, and for each we require effective treatments. PubMed, Exp Dermatol, 08/25/2020. (Also see Skin Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  16. Translational engagement of lysophosphatidic acid receptor 1 (LPA1) in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse. Our results support the therapeutic potential of LPA1 receptor antagonists in systemic sclerosis. PMC, Br J Pharmacol, 2020 Sep; 177(18): 4296-4309. (Also see Skin Fibrosis and Fibroblasts) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  17. The Role of Fecal Calprotectin in Patients with Systemic Sclerosis (SSc) and Small Intestinal Bacterial Overgrowth (SIBO). The development of SIBO in SSc patients, when associated with intense gastrointestinal symptoms and frequent diarrhoea often leads to malabsorption and malnutrition. PMC, Diagnostics (Basel), 2020 Aug; 10(8): 587. (Also see Bowel Dysfunction) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  18. Gastric Juice Expression of Th-17 and T-Reg Related Cytokines in Scleroderma Esophageal Involvement. This is the first report of cytokines measurement in gastric juice of patients with SSc. PubMed, Cells, 2020 Sep 16;9(9):E2106. (Also see Esophageal (Throat) Involvement and Cytokines) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  19. Machine learning predicts stem cell transplant (HSCT) response in severe scleroderma (SSc). This study suggests that intrinsic subset stratification of patients may be used to identify patients with SSc who receive significant benefit from HSCT. PubMed, Ann rheumatologist Dis, 2020 Sep 15;annrheumdis-2020-217033. (Also see Stem Cell Transplantation) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  20. Subclinical atherosclerosis in systemic sclerosis (SSc) and rheumatoid arthritis (RA): a comparative matched-cohort study. The results of this comparative study show that subclinical atherosclerosis is comparable between SSc and RA, a systemic disease with well-defined high atherosclerotic burden. PubMed, Rheumatol Int, 08/08/2020. (Also see Cardiac (Heart) Involvement and Symptoms and Complications of Rheumatoid Arthritis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  21. Scleroderma of the Hand: Evaluation and Treatment. The spectrum of hand manifestations seen in patients with scleroderma will be reviewed with the focus on evaluation and management. PubMed, J Am Acad Orthop Surg, 2020 Aug 15;28(16):e686-e695. (Also see Hand and Joint Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  22. Association of functional (GA)n microsatellite polymorphism in the FLI1 gene with susceptibility to human systemic sclerosis (SSc). Extended repeat alleles of FLI1 (GA)n microsatellite may be associated with lower FLI1 mRNA levels and susceptibility to human SSc. PubMed, Rheumatology (Oxford), 2020 Jul 22;keaa306. (Also see Genetics) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  23. Systemic Sclerosis (SSc) Is an Independent Risk Factor for Ischemic Heart Disease (IHD), Especially in Patients Carrying Certain Antiphospholipid Antibodies. Patients with SSc are at higher risk for developing IHD with an additional risk for the latter in those positive for anti-cardiolipin or anti-beta2GPI. PubMed, Eur J Intern Med, 06/30/2020. (Also see Cardiac (Heart) Involvement and Antiphospholipid Syndrome) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  24. Cardiovascular Risk Factors and Atherosclerotic Cardiovascular (CV) Events Among Incident Cases of Systemic Sclerosis (SSc). Patients with SSc are at ⦥2-fold increased risk for experiencing a CV event compared with persons without SSc. PubMed, Mayo Clin Proc, 2020 Jul;95(7):1369-1378. (Also see Vascular Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  25. Serious Infections in People With Systemic Sclerosis: A National US Study. Outcomes in people with SSc hospitalized with serious infections have improved over time. PubMed, Arthritis Res Ther, 2020 Jun 29;22(1):163. (Also see Infection) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
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