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  1. Hi All, SCLERO.ORG is retiring 4-24-2021. Thank you for the memories! You'll still find us in the Wayback Machine, and we'll carry your stories in our hearts forever. Best wishes,
  2. Cardiovascular Autonomic Control, Sleep and Health Related Quality of Life in Systemic Sclerosis (SSc). Dysautonomia and chronic pain showed a severe impact on sleep quality and disability with a consequent worsening of depressive symptom in our cohort of SSc patients. PubMed, Int J Environ Res Public Health, 2021 Feb 25;18(5):2276. (Also see Brain (Cerebral) Involvement and Sleep Disorders) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  3. Case Report: Novel case of a scleroderma-mimicking syndrome associated with gastrointestinal stromal tumour (GIST). While there have been previous descriptions of paraneoplastic fibrotic disorders, this is the first description of a scleroderma mimic in the setting of a GIST. PubMed, BMJ Case Rep. (Also see Gastrointestinal Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  4. Congruent microbiome signatures in fibrosis-prone autoimmune diseases: IgG4-related disease and systemic sclerosis. These results provide an initial characterization of gut microbiome ecology in fibrosis-prone IgG4-RD and SSc and reveal microbial functions that offer insights into the pathophysiology of these rare diseases. PubMed, Genome Med, 2021 Feb 28;13(1):35. (Also see Gastrointestinal Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles
  5. Progression of gastrointestinal (GI) symptoms over time in patients with systemic sclerosis (SSc). Patients with SSc generally demonstrate longitudinal stability or improvement in their GI symptoms, but a subset of patients experience worsening of GI symptoms and negative impacts on GI-related quality of life. PubMed, Rheumatol Int, 02/25/2021. (Also see Gastrointestinal Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  6. Prevalence of retinal changes in patients with systemic sclerosis (SSc): the association between retinal vascular changes and nailfold capillaroscopic findings. There was no correlation between nailfold capillaroscopy, disease duration, type and skin score of SSc patients and retinal vascular changes. PubMed, Reumatologia, 2021;59(1):27-34. (Also see Eye Involvement and Common Medical Tests) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  7. Poor maternal and foetal outcomes in women with systemic sclerosis (SSc): an interview-based study at a tertiary centre. Poor obstetric outcomes are described in rheumatic diseases (RDs) such as SSc and SSc incurs a higher risk of poor maternal as well as the foetal outcome. PubMed, Rheumatol Int, 03/08/2021. (Also see Pregnancy and Systemic Scleroderma) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  8. Hi All, SCLERO.ORG is retiring 4-24-2021. Thank you for the memories! You'll still find us in the Wayback Machine, and we'll carry your stories in our hearts forever. Best wishes,
  9. Hi All, SCLERO.ORG is retiring 4-24-2021. Thank you for the memories! You'll still find us in the Wayback Machine, and we'll carry your stories in our hearts forever. Best wishes,
  10. Hi All, SCLERO.ORG is retiring 4-24-2021. Thank you for the memories! You'll still find us in the Wayback Machine, and we'll carry your stories in our hearts forever. Best wishes,
  11. Hi All, SCLERO.ORG is retiring 4-24-2021. Thank you for the memories! You'll still find us in the Wayback Machine, and we'll carry your stories in our hearts forever. Best wishes,
  12. Hi All, SCLERO.ORG is retiring 4-24-2021. Thank you for the memories! You'll still find us in the Wayback Machine, and we'll carry your stories in our hearts forever. Best wishes,
  13. Autoantibodies targeting telomere-associated proteins in systemic sclerosis. Autoantibodies targeting telomere-associated proteins in a subset of patients with SSc are associated with short lymphocyte telomere length and lung disease. PubMed, Ann rheumatologist Dis, 2021 Jan 25;annrheumdis-2020-218918. (Also see Antibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  14. Implication of miR-126 and miR-139-5p in Plasmacytoid Dendritic Cell (pDCs) Dysregulation in Systemic Sclerosis (SSc). These findings demonstrated that the miRNA profile is altered in pDCs of SSc patients already at early stages of the disease. PubMed, J Clin Med, 2021 Jan 30;10(3):491. (Also see Dendritic Cells) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  15. Prevalence and clinical association with calcinosis cutis in early systemic sclerosis (SSc). Occult calcinosis cutis can be detected by hand radiograph in one half of SSc patients at early onset of the disease. PubMed, Mod Rheumatol, 2021 Feb 10;1-19. (Also see Calcinosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  16. Prediction and primary prevention of major vascular complications (MVC) in systemic sclerosis (SSc). In SSc patients, our data confirm the role of arthritis and dyspnea as independent predictors of major vascular complications, in particular in MVCs-naïve patients. PubMed, Eur J Intern Med, 2021 Feb 5;S0953-6205(21)00022-4. (Also see Vascular Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  17. Scleroderma Renal Crisis (SRC). There is an urgent need to improve early recognition and treatment, and to identify novel treatments to improve outcomes of SRC. PubMed, Presse Med, 2021 Feb 3;104063. (Also see Kidney (Renal) Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  18. Identifying early pulmonary arterial hypertension (PAH) biomarkers in systemic sclerosis (SSc): Machine learning on proteomics from the DETECT cohort. This novel 8-protein biomarker panel has the potential to improve early detection of PAH in SSc patients and may provide novel insights into the pathogenesis of PAH in the context of SSc. PubMed, Eur Respir J, 2020 Dec 17;2002591. (Also see Prognosis of Pulmonary Hypertension) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  19. Effect of bosentan in pulmonary hypertension development in systemic sclerosis (SSc) patients with digital ulcers. We concluded that SSc patients with digital ulcers treated with bosentan seems to have less risk to develop pulmonary hypertension and to stabilize carbon monoxide diffusing capacity. PubMed, PLoS One, 2020 Dec 10;15(12):e0243651. (Also see Tracleer (Bosentan)) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  20. More Than 40% of Scleroderma Patients Have Bone Density Loss, Study Finds. More than 40% of scleroderma patients are diagnosed with osteopenia or osteoporosis and the risk is increased by time from first symptom and with the use of immunosuppressants, a study has found. Scleroderma News, 12/15/2020. (Also see Osteoporosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  21. Does sublingual microscopy correlate with nailfold videocapillaroscopy in systemic sclerosis (SSc)? Nailfold and sublingual microscopy can identify a loss of capillary density in SSc patients. PubMed, Clin Rheumatol, 01/07/2021. (Also see Vascular Involvement and Nailfold Capillaroscopy) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  22. A Real–World Experience of Mycophenolate Mofetil (MMF) for Systemic Sclerosis (SSc): A Retrospective Multicenter Observational Study. This real-world based study supports the role of MMF in the stabilization of lung function and the improvement in skin thickness with an acceptable safety profile in patients with SSc. PubMed, Arch Rheumatol, 2020 Jan 13;35(3):366-375. (Also see Immunosuppressants) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  23. Factors associated with fears due to COVID-19: A scleroderma patient-centered intervention network (SPIN) COVID-19 cohort study. Fears due to COVID-19 were associated with clinical and functional vulnerabilities in this chronically ill population. PubMed, J Psychosom Res, 2020 Nov 25;140:110314. (Also see Anxiety and Attitude) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  24. Risk of death among people with rare autoimmune rheumatic diseases (RAIRD) compared to the general population in England during the 2020 COVID-19 pandemic. The risk of all-cause death is more prominently raised during COVID-19 among people with RAIRD than among the general population. PubMed, Rheumatology (Oxford), 2020 Dec 4;keaa855. (Also see Prognosis and Mortality) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  25. Increased expression of interferon regulated and antiviral response genes in CD31+/CD102+ lung microvascular endothelial cells from systemic sclerosis patients with end-stage interstitial lung disease. These observations suggest that interferon-induced and antiviral response proteins may participate in the pathogenesis of SSc vasculopathy and SSc-ILD. PubMed, Clin Exp Rheumatol, 11/17/2020. (Also see Pulmonary Fibrosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
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