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Found 87 results

  1. Racial differences in systemic sclerosis (SSc) disease presentation: a European Scleroderma Trials and Research group study. We evaluated differences in SSc presentations between white patients, Asian patients and black patients and analysed the effects of geographical locations. PubMed, Rheumatology (Oxford), 11/04/2019. (Also see Ethnicity, Race and Geographical Regions) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  2. The Roles of IL-1 Family Cytokines in the Pathogenesis of Systemic Sclerosis (SSc). Here, we aim to give a brief overview of IL-1 family cytokines and discuss their pivotal roles in the pathogenesis of SSc. PubMed, Front Immunol, 2019 Sep 13;10:2025. (Also see Interleukins) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  3. Increased prevalence of small airways dysfunction in patients with systemic sclerosis (SSc) as determined by impulse oscillometry. A full assessment of lung function in SSc patients should include impulse oscillometry as a complementary technique, due to potential clinical and therapeutic implications. PubMed, Rheumatology (Oxford), 08/22/2019. (Also see Pulmonary Fibrosis Diagnosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  4. Potential Cannabidiol Treatment EHP-101 Shows Safety in Early Trial, Study in Scleroderma Patients Being Readied. EHP-101, an oral cannabidiol treatment candidate for people with scleroderma (SSc) and multiple sclerosis (MS), was found to be safe and well-tolerated in a Phase 1 clinical trial in healthy volunteers. Scleroderma News, 08/28/2019. (Also see Endocannabinoid System) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  5. Revised European Scleroderma (SSc) Trials and Research Group Activity Index is the best predictor of short-term severity accrual. The adjusted mean EUSTAR-AI has the best predictive value for disease progression and development of severe organ involvement over time in SSc. PubMed, Ann rheumatologist Dis, 08/17/2019. (Also see Prognosis and Mortality) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  6. Ethnic Variations in Systemic Sclerosis (SSc) Disease Manifestations, Internal Organ Involvement, and Mortality. Ethnic variations in some SSc disease manifestations are observed, but this does not result in significant differences in short-term survival but may affect long-term survival. PubMed, J Rheumatol, 2019 Sep;46(9):1103-1108. (Also see Ethnicity, Race and Geographical Regions) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  7. Health-related quality of life (HRQoL) in systemic sclerosis (SSc) before and after autologous haematopoietic stem cell transplant (AHSCT) - a systematic review. AHSCT in severe SSc patients is associated with significant and durable improvement in physical HRQoL. PubMed, Rheumatology (Oxford), 08/27/2019. (Also see Stem Cell Transplantation and Quality of Life) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  8. Case Report: Total gastrectomy in systemic scleroderma when anti-reflux surgery is not viable. We suggest an open gastrectomy with roux-en-Y anastomosis as an alternative to the Nissen fundoplication for patients with connective tissue disease. PubMed, Int J Surg Case Rep. (Also see Reflux (Heartburn) Prevention and Treatments) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  9. The Relationship Between Autonomic Dysfunction of the Gastrointestinal (GI) Tract and Emotional Distress in Patients With Systemic Sclerosis (SSc). In SSc, increased symptom burden related to GI dysautonomia is associated with emotional distress. PubMed, J Clin Rheumatol, 09/12/2019. (Also see Bowel Dysfunction and Coping with Scleroderma) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  10. Sarcopenia in systemic sclerosis: the impact of nutritional, clinical, and laboratory features. The results of this study demonstrated that sarcopenia correlates with different nutritional, clinical, and biochemical parameters associated with the worsening of SSc. PubMed, Rheumatol Int, 08/01/2019. (Also see Myopathy and Myositis and Osteoporosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  11. Anti-cancer Therapy May Help Fight Inflammation in Scleroderma (SSc) Patients, Data Suggest. These results suggest that tagraxofusp might be a potential therapeutic approach for SSc or other autoimmune diseases. Scleroderma News, 06/26/2019. (Also see Cancer and Dendritic Cells) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  12. Higher estrogen levels linked to more severe disease in scleroderma. Higher estradiol levels were associated with more severe disease and heart involvement in men and in those positive for the autoantibody Scl-70, a greater risk of death. Science Daily, 06/06/2019. (Also see Hormones) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  13. I think I have the best son in the world. We were out trimming weeds from around the air conditioning unit. I was pulling the little ones that came out easily and I really cannot tell any one what happened. Luckily my head hit the lawn instead of the sidewalk; I missed the sidewalk by inches. My son got me into the house and sat with me until he was sure I did not have a concussion. I'm so thankful that I had him. I send you all a blessing. I would love to hear stories of some one or thing that touched your heart. Oh, I am ok and headed to bed.
  14. I’m always wanting to go to any one of my doctors and hear “you are doing great, we don't need to do anymore tests or change your medications”. But that is only a dream. I saw my gastroenterologist Monday; my choking is getting worse, the part that opens and closes is getting smaller and the part in my throat between c4-c5 is getting harder. The funny thing about this is, it is not the little uncoated pills, which go down better than the coated capsules. An appointment is being made to see a speech therapist. I was also told I can open the capsule and crush the others, except the pain meds and the one I can not say, let alone spell! A good friend tells me to always remember to say it is what it is. My son is now living with me; it is so nice to have support in the home. I wi!I be keeping my thoughts about everyone that has scleroderma. Quiltfairy.
  15. Low RUNX3 expression alters dendritic cell function in patients with systemic sclerosis (SSc) and contributes to enhanced fibrosis. We show at least two pathways potentially causing low runt-related transcription factor 3 level in SSc plasmacytoid dendritic cells. PubMed, Ann rheumatologist Dis, 05/24/2019. (Also see Dendritic Cells) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  16. Common Causes of Pain in Systemic Sclerosis (SSc): Frequency, Severity, and Relationship to Disease Status, Depression, and Quality of Life. The majority of patients with SSc suffer from different types of pain which is associated with more severe disease, depression and poor quality of life. PubMed, Pain Manag Nurs, 05/15/2019. (Also see Pain Management) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  17. Serum concentrations of IL-17A, IL-17B, IL-17E and IL-17F in patients with systemic sclerosis (SSc). Increased synthesis of IL-17B, IL-17E and IL-17F appears to play a role in the pathogenesis of SSc, in contrast to IL-17A. PubMed, Arch Med Sci, 2019 May;15(3):706-712. (Also see Interleukins) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  18. Gastrointestinal manifestations on impaired quality of life in systemic sclerosis (SSc). Gastrointestinal involvement is frequent in SSc, with reflux or indigestion as the most common symptom. PubMed, J Dig Dis, 2019 May;20(5):256-261. (Also see Gastrointestinal Involvement and Quality of Life) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  19. Capillaroscopy changes are associated with disease progression in patients with early systemic sclerosis (SSc): A prospective study. An active or a late pattern on capillaroscopy was an independent predictive risk factor for the development of SSc. PubMed, Int J rheumatologist Dis, 05/02/2019. (Also see Nailfold Videocapillaroscopy) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  20. Interleukin-17 pathways in systemic sclerosis–associated fibrosis. There is multitude of evidence from across different tissues that interleukin-17 (IL-17) and its downstream pathways are strongly associated with the initiation and propagation of fibrosis. PubMed, Rheumatol Int, 05/09/2019. (Also see Interleukins and Skin Fibrosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  21. Validation of the REVEAL Prognostic Equation and Risk Score Calculator in Incident Systemic Sclerosis-Associated Pulmonary Arterial Hypertension. In predicting one–year survival in newly diagnosed SSc–PAH, the REVEAL prognostic equation and risk score provide very good discrimination but poor calibration. PubMed, Arthritis Rheumatol, 05/08/2019. (Also see Prognosis of Pulmonary Hypertension) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  22. Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma. In vivo, TLY012 reverses established skin fibrosis to near–normal skin architecture in mouse models of scleroderma. PubMed, Nat Commun, 2019 Mar 8;10(1):1128. (Also see Fibroblasts) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  23. Incidental significant arrhythmia in scleroderma (SSc) associates with cardiac magnetic resonance measure of fibrosis and hs-TnI and NT-proBNP. This first implantable loop recorder study identified potentially life–threatening arrhythmias in asymptomatic SSc patients attributable to a primary SSc heart disease. PubMed, Rheumatology (Oxford), 01/28/2019. (Also see Complications with SSc Heart Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  24. My name is Blair. In June of 2018 my daughter, who was seven years old at the time, was diagnosed with En coup de Sabre and has been on treatment since. Upon doing my own research, I have found that there is a possible link between silicone breast implants and auto immune diseases such as Scleroderma. I am wondering now because I have silicone breast implants and breast fed my daughter when she was a baby if there is any sort of connection between the two. Just reaching out to see if anyone else has this situation.
  25. New Computer–based Analysis Method Identifies Scleroderma Patients Who May Benefit Most from Stem Cell Transplant. The analysis of gene profile in blood samples may help identify scleroderma patients who could benefit most from stem cell transplant, a research study suggests. Scleroderma News, 11/01/2018. (Also see Stem Cell (Bone Marrow) Transplantation) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
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