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  1. Frontiers in translational systemic sclerosis (SSc) research: a focus on the unmet 'cutaneous' clinical needs (Viewpoint). This viewpoint considers four cutaneous unmet clinical needs of patients with Ssc, which cause pain, disability, and/or disfigurement, all impact on quality of life, and for each we require effective treatments. PubMed, Exp Dermatol, 08/25/2020. (Also see Skin Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  2. Translational engagement of lysophosphatidic acid receptor 1 (LPA1) in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse. Our results support the therapeutic potential of LPA1 receptor antagonists in systemic sclerosis. PMC, Br J Pharmacol, 2020 Sep; 177(18): 4296-4309. (Also see Skin Fibrosis and Fibroblasts) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  3. The Role of Fecal Calprotectin in Patients with Systemic Sclerosis (SSc) and Small Intestinal Bacterial Overgrowth (SIBO). The development of SIBO in SSc patients, when associated with intense gastrointestinal symptoms and frequent diarrhoea often leads to malabsorption and malnutrition. PMC, Diagnostics (Basel), 2020 Aug; 10(8): 587. (Also see Bowel Dysfunction) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  4. Gastric Juice Expression of Th-17 and T-Reg Related Cytokines in Scleroderma Esophageal Involvement. This is the first report of cytokines measurement in gastric juice of patients with SSc. PubMed, Cells, 2020 Sep 16;9(9):E2106. (Also see Esophageal (Throat) Involvement and Cytokines) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  5. Machine learning predicts stem cell transplant (HSCT) response in severe scleroderma (SSc). This study suggests that intrinsic subset stratification of patients may be used to identify patients with SSc who receive significant benefit from HSCT. PubMed, Ann rheumatologist Dis, 2020 Sep 15;annrheumdis-2020-217033. (Also see Stem Cell Transplantation) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  6. Subclinical atherosclerosis in systemic sclerosis (SSc) and rheumatoid arthritis (RA): a comparative matched-cohort study. The results of this comparative study show that subclinical atherosclerosis is comparable between SSc and RA, a systemic disease with well-defined high atherosclerotic burden. PubMed, Rheumatol Int, 08/08/2020. (Also see Cardiac (Heart) Involvement and Symptoms and Complications of Rheumatoid Arthritis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  7. Scleroderma of the Hand: Evaluation and Treatment. The spectrum of hand manifestations seen in patients with scleroderma will be reviewed with the focus on evaluation and management. PubMed, J Am Acad Orthop Surg, 2020 Aug 15;28(16):e686-e695. (Also see Hand and Joint Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  8. Association of functional (GA)n microsatellite polymorphism in the FLI1 gene with susceptibility to human systemic sclerosis (SSc). Extended repeat alleles of FLI1 (GA)n microsatellite may be associated with lower FLI1 mRNA levels and susceptibility to human SSc. PubMed, Rheumatology (Oxford), 2020 Jul 22;keaa306. (Also see Genetics) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  9. Systemic Sclerosis (SSc) Is an Independent Risk Factor for Ischemic Heart Disease (IHD), Especially in Patients Carrying Certain Antiphospholipid Antibodies. Patients with SSc are at higher risk for developing IHD with an additional risk for the latter in those positive for anti-cardiolipin or anti-beta2GPI. PubMed, Eur J Intern Med, 06/30/2020. (Also see Cardiac (Heart) Involvement and Antiphospholipid Syndrome) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  10. Cardiovascular Risk Factors and Atherosclerotic Cardiovascular (CV) Events Among Incident Cases of Systemic Sclerosis (SSc). Patients with SSc are at ⦥2-fold increased risk for experiencing a CV event compared with persons without SSc. PubMed, Mayo Clin Proc, 2020 Jul;95(7):1369-1378. (Also see Vascular Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  11. Serious Infections in People With Systemic Sclerosis: A National US Study. Outcomes in people with SSc hospitalized with serious infections have improved over time. PubMed, Arthritis Res Ther, 2020 Jun 29;22(1):163. (Also see Infection) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  12. An update on the pharmacotherapeutic options and treatment strategies for systemic sclerosis. Combining therapies to address the individual manifestations of SSc is a cornerstone to the comprehensive management of this condition. PubMed, Expert Opin Pharmacother, 2020 Jul 17;1-15. (Also see Treatments - General) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  13. TLY012 Receives FDA Orphan Drug Status for Systemic Scleroderma. An early study showed that TLY012 killed skin myofibroblasts from people with scleroderma, while it did not have the same effect in cells derived from people without the disease. Scleroderma News, 05/31/2020. (Also see Fibroblasts) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  14. Recommendations for Diagnosing and Managing Systemic Sclerosis. The combined management of DUs can improve both the onset of new DUs and DU's healing thus leading to a better outcome. PubMed, Transl Med UniSa, 2020 May 31;22:10-14. (Also see Topical Treatments) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  15. Renal Involvement in Systemic Sclerosis: An Update. There is a strong association between renal involvement and patients' outcomes in systemic sclerosis. PubMed, Kidney Blood Press Res, 2020 Jun 10;1-17. (Also see Kidney (Renal) Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  16. The Systemic Sclerosis Patient in the COVID-19 Era: The Challenging Crossroad Between Immunosuppression, Differential Diagnosis and Long-Term Psychological Distress. The rheumatologist in daily clinical practice should carefully differentiate the possible COVID-19 infection in order to optimize the patient management. PubMed, Clin Rheumatol, 2020 Jun 8;1-5. (Also see Correlation between Pulmonary Fibrosis and other Diseases or Complications) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  17. Interleukin-32 in Systemic Sclerosis (SS), a Potential New Biomarker for Pulmonary Arterial Hypertension (PAH) Our study suggested that sera determination of IL-32 may be a promising approach to evaluate the presence of PAH in SSc patients. PubMed, Arthritis Res Ther, 2020 Jun 1;22(1):127. (Also see Interleukins and Pulmonary Hypertension Diagnosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  18. Ultrasound (US) Detection of Calcinosis and Association With Ulnar Artery Occlusion in Patients With Systemic Sclerosis (SSc). US was sensitive and highly specific in detecting calcinosis in SSc. PubMed, Arthritis Care Res (Hoboken), 05/31/2020. (Also see Calcinosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  19. Older age onset of systemic sclerosis (SSc) - accelerated disease progression in all disease subsets. In this large registry, 25% of patients developed SSc at an age above 60 years with an increased frequency of limited cutaneous systemic sclerosis. PubMed, Rheumatology (Oxford), 04/24/2020. (Also see Causes of Scleroderma) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  20. Long-standing morphea and the risk of squamous cell carcinoma of the skin (cSCC). Fibrosis, inflammation and chronic ulcerations may eventually promote skin neoplasms; morphea is therefore a rare but established risk factor for cSCC. PubMed, J Dtsch Dermatol Ges, 05/04/2020. (Also see Causes of Morphea) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  21. Systemic Sclerosis and Vaccinations. Age over 65 years old, interstitial lung disease, and ongoing immunosuppressive therapy were significantly related with acceptance to both vaccinations using univariate analyses. PubMed, Vaccines (Basel), 2020 Apr 28;8(2). (Also see Vaccinations) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  22. Effect of a tailored home-based exercise program in patients with Systemic Sclerosis (SSc): a randomized controlled trial. This study indicates that in SSc patients a minimally supervised, home-based exercise program improves physical performance, quality of life and disability in comparison to usual care. PubMed, Scand J Med Sci Sports, 04/29/2020. (Also see Coping Strategies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  23. Comparative analysis of affected and unaffected areas of systemic sclerosis (SSc) skin biopsies by high-throughput proteomic approaches. We identified a number of proteins and pathways that might be involved in SSc progression and pathogenesis. PubMed, Arthritis Res Ther, 2020 May 7;22(1):107. (Also see Skin Fibrosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  24. Silica Exposure and Scleroderma: More Bridges and Collaboration between Disciplines Are Needed. The lack of a proper understanding of the pathogenesis of silica-associated autoimmunity may also result from missing bridges between disciplines. PMC, Am J Respir Crit Care Med, 2020 Apr 1; 201(7): 880–882. (Also see Silica Exposure) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  25. Antigen-specific (Ab) humoral responses against Helicobacter pylori (Hp) in patients with systemic sclerosis (SSc). Anti-Hp Abs are neither more frequent nor elevated in SSc compared with healthy population and these results suggest that Hp is unlikely to be involved in the development of SSc. PubMed, Immunol Res, 04/06/2020. (Also see Antibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
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