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Silica Exposure and Scleroderma: More Bridges and Collaboration between Disciplines Are Needed. The lack of a proper understanding of the pathogenesis of silica-associated autoimmunity may also result from missing bridges between disciplines. PMC, Am J Respir Crit Care Med, 2020 Apr 1; 201(7): 880–882. (Also see Silica Exposure) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.