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Two subgroups in systemic lupus erythematosus (SLE) with features of antiphospholipid (APS) or Sjögren's syndrome (SS) differ in molecular signatures and treatment perspectives. Stratifying SLE patients based on an autoantibody profile could be a way forward to understand underlying pathophysiology and to improve selection of patients for clinical trials of targeted treatments. PubMed, Arthritis Res Ther, 2019 Feb 18;21(1):62. (Also see Lupus in Overlap, Sjögren's Syndrome and Antiphospholipid Syndrome) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles. 

Started on Plaquenil at 200mg a day for 2 weeks, and have been on 400 mg a day for a little over a week - which is my maintenance dose. I have been feeling extremely fatigued, but now also am having terrible mood changes and feel terribly depressed at times. I am concerned that if I stop taking the Plaquenil, I will start having more episodes of acute arthritic arthritis - which are terribly painful and usually put me in hospital. I have not been offered any alternatives. I have had scleroderma for approx 20 years without being given any DMARD's.

Physical activity but not sedentary activity is reduced in primary Sjögren's syndrome (PSS). Physical, but not sedentary, activity is reduced in people with PSS and is associated with symptoms of depression and daytime sleepiness. PubMed, Rheumatol Int, 12/24/2016. (Also see Sjögren's Syndrome) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.