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Found 35 results

  1. The anti-aging protein alpha-Klotho in systemic sclerosis patients: does a relationship to telangiectasia exist? An imbalance in serum α-Klotho levels may be involved in systemic sclerosis. PubMed, Z Rheumatol, 10/10/2019. (Also see Telangiectasia) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  2. Systemic sclerosis (SSc) medications and risk of scleroderma renal crisis (SRC). Ace inhibitor (ACEi) use at SSC diagnosis was associated with an increased risk for SRC and so SSC patients that require ACEi should be more closely monitored for SRC. PubMed, BMC Nephrol, 2019 Jul 25;20(1):279. (Also see Scleroderma Renal Crisis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  3. Association of simple hematological parameters with disease manifestations, activity, and severity in patients with systemic sclerosis (SSc). Globally available and inexpensive hematological tests, may be associated with vascular and cutaneous manifestations as well as disease activity and severity in SSc. PubMed, Clin Rheumatol, 07/18/2019. (Also see Vascular Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  4. Performance of a new quantitative computed tomography index for interstitial lung disease (ILD) assessment in systemic sclerosis (SSc). This new composite CT index for SSc-ILD assessment could be sufficiently sensitive for capturing early lung density changes in visually ILD-free patients. PubMed, Sci Rep, 2019 Jul 1;9(1):9468. (Also see Pulmonary Fibrosis Diagnosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  5. A comprehensive analysis of antigen-specific antibody responses against human cytomegalovirus (HCMV) in patients with systemic sclerosis (SSc). More prevalent and/or stronger antigen-specific HCMV responses are noted in SSc compared to controls, implying a role of these viral responses in SSc development. PubMed, Clin Immunol, 07/29/2019. (Also see Antibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  6. IL-16 expression is increased in the skin and sera of patients with systemic sclerosis. The regional up-regulation of IL-16 in the skin is not only associated with skin sclerosis, but also with systemic IL-16 activation. PubMed, Rheumatology (Oxford), 08/03/2019. (Also see Skin Fibrosis and Interleukins) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  7. Clinical Manifestation and Incidence of Cardiopulmonary Complications in Early Systemic Sclerosis (SSc) Patients with Different Antibody Profiles. It was found that the presence of SSc-specific autoantibodies was associated with a distinctive clinical presentation and cumulative internal organ involvement, even in the early phase of the disease. PubMed, J Clin Med Res, 2019 Jul;11(7):524-531. (Also see Antibodies and Research about Scleroderma Cardiac (Heart) Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  8. Colonic and Anorectal Manifestations of Systemic Sclerosis. Colonic and anorectal manifestations of systemic sclerosis include constipation, diarrhea, and fecal incontinence, and can diminish quality of life for these patients. PubMed, Curr Gastroenterol Rep, 2019 Jul 8;21(7):33. (Also see Bowel Dysfunction) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  9. Cancers in systemic sclerosis (Ssc) : risk factors, impact on survival and literature review. The history of renal scleroderma crisis and the positivity of anti-topoisomerase I antibodies were associated with an increased risk of cancer in SSc patients in this monocentric study. PubMed, Rev Med Interne, 06/26/2019. (Also see Cancer) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  10. Autoantibodies are present before the clinical diagnosis of systemic sclerosis (SSc). Our findings demonstrate that relevant seropositive autoantibodies often precede the clinical diagnosis of Ssc/no scleroderma renal crisis (SRC) and SSc/SRC. PubMed, PLoS One, 2019 Mar 26;14(3):e0214202. (Also see Antibodies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  11. Cannabinoid derivatives acting as dual PPARγ/CB2 agonists as therapeutic agents for systemic sclerosis (SSc). Altogether the results indicate that dual PPARγ/CB2 agonists qualify as a novel therapeutic approach for the treatment of SSc and other fibrotic diseases. PubMed, Biochem Pharmacol, 2019 Feb 27;163:321-334. (Also see Endocannabinoid System) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  12. Phenotypes determined by cluster analysis and their survival in the prospective EUSTAR cohort of patients with systemic sclerosis (SSc). Our work suggests that restricting the subsets of SSc patients only to the cutaneous involvement may not capture the complete heterogeneity of the disease. PubMed, Arthritis Rheumatol, 04/10/2019. (Also see Cluster Studies) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  13. Factors influencing Raynaud's condition score diary outcomes in systemic sclerosis. Patient–reported assessment of SSc–RP severity is associated with a number of factors including pain, catastrophisation and coping strategies. PubMed, J Rheumatol, 03/01/2019. (Also see Raynaud's) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles. 
  14. Case Report: Maxillofacial Implications of Scleroderma and Systemic Sclerosis. We present the case of a 26-year-old female patient with scleroderma who exhibited extreme maxillofacial manifestations of the disease. PubMed, J Oral Maxillofac Surg. (Also see Dental Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles. 
  15. Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis (SSc) skin. These data provide a comprehensive portrait of the SSc skin microbiome and its association with local gene expression. PubMed, Arthritis Res Ther, 2019 Feb 6;21(1):49. (Also see Skin Fibrosis) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  16. Type I interferon dysregulation in Systemic Sclerosis. Here we describe the evidence of Type I IFN dysregulation in SSc, revealed predominately by genetics and gene expression profiling. PubMed, Cytokine, 01/23/2019. (Also see Cytokines) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  17. Effects of treatment with rituximab on microcirculation in patients with long–term systemic sclerosis. Rituximab improves microcirculation in long–term SSc and stabilization and reduced progression of microcirculation abnormalities were achieved. PubMed, BMC Res Notes, 2018 Dec 10;11(1):874. (Also see Biologic Agents and Clinical Trials) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  18. Median neuropathy at the wrist (MNW) in patients with systemic sclerosis (SSc): two–year follow–up study. MNW commonly has high incidence in SSc patients and therefore, SSc patients should be followed up in both clinical and electrodiagnostic studies for MNW screening. PubMed, Reumatologia, 2018;56(5):294-300. (Also see Hand and Joint Involvement) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  19. Potential occupational and environmental factors in systemic sclerosis (SSc) onset. Although the pathogenesis of scleroderma remains unclear, there is a marked correlation between the onset of SSc and certain environmental or occupational factors. PubMed, Ann Agric Environ Med, 2018 Dec 19;25(4):596-601. (Also see Causes of Scleroderma: Environmental) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  20. Prevalence and Clinical Associations of Antiphospholipid Antibodies (aPL) in Systemic Sclerosis (SSc): New Data From a French Cross–Sectional Study, Systematic Review, and Meta–Analysis. In our SSc population, aPL positivity was associated with venous thrombosis and miscarriage and these data provide additional insights into the role of aPL in the vasculopathy observed in SSc. PubMed, Front Immunol, 2018 Nov 2;9:2457. (Also see Antiphospholipid Syndrome) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  21. Analysis of serum macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase in systemic sclerosis (SSc). Although not significantly linked to specific clinical parameters, serum MIF was significantly higher in SSc patients than in healthy controls and systemic lupus erythematosus patients. PubMed, Clin Transl Immunology, 2018 Dec 6;7(12):e1042. (Also see Cytokines) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  22. A Potential Link Between Oxidative Stress and Endothelial–to–Mesenchymal Transition (EndMT) in Systemic Sclerosis (SSc). We identified studies investigating associations reactive oxygen species and EndMT highlighting a potential link between oxidative stress and EndMT in SSc. PubMed, Front Immunol, 2018 Sep 19;9:1985. (Also see Oxidative Stress) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  23. Champion bagpiper's fingers turned BLACK and had to be amputated after he contracted gangrene which nearly killed him. A champion bagpipe player had to have all his fingers and toes amputated after he developed gangrene which nearly killed him. Mail Online, 09/21/2018. (Also see Gangrene and Amputation) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  24. Treatment of small intestinal bacterial overgrowth (SIBO) in systemic sclerosis (SSc): a systematic review. For some SSc patients, antibiotics can eradicate SIBO and there is a paucity of data reporting the effectiveness of either prokinetics or probiotics in SSc. PubMed, Rheumatology (Oxford), 07/02/2018. (Also see Bowel Dysfunction) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
  25. A Feasibility Study of a Novel Low Level Light Therapy (LTTT) for Digital Ulcers (DUs) in Systemic Sclerosis. LTTT for DUs is safe, feasible and well tolerated. There was an early tentative suggestion of treatment efficacy. PubMed, J Dermatolog Treat, 2018 Jun 4:1-30. (Also see Treatments for Digital Ulcers) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
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