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The anti-aging protein alpha-Klotho in systemic sclerosis patients: does a relationship to telangiectasia exist? An imbalance in serum α-Klotho levels may be involved in systemic sclerosis. PubMed, Z Rheumatol, 10/10/2019. (Also see Telangiectasia) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.