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Cardiac involvement in undifferentiated connective tissue disease (UCTD) at risk for systemic sclerosis (SSc) (otherwise referred to as very early–early systemic sclerosis): a TDI study. Our study shows that UCTD–risk–SSc patients show a previously unrecognized, mild biventricular systolic and diastolic dysfunction as compared to controls. PubMed, Clin Exp Med, 2018 May;18(2):237-243. (Also see Undifferentiated Connective Tissue Disease) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.
Hello. First post here. I am having some concerning symptoms and blood work and my various web searches have brought me to this forum. I am 42 years old and have had Hashimoto's thyroiditis for about 25 years. I have been taking thyroid medication since then and have monitored it closely. My current symptoms are mild Raynaud's, mild dry eyes/mouth and fatigue. I also have a serious case of Oral Lichen Planus which began about 3 months ago and is only getting worse and more bothersome. I am prone to tendonitis which resolves with rest. I do not have any skin thickening, joint pain, digestive or lung issues at this time. It was the Lichen Planus that caused an ENT to check my ANA and when that came back positive I saw a rheumatologist to investigate further. My blood work shows a low positive ANA (1:80), positive ACA (around 3), Hashimoto's antibody (can't remember the name) and deficiencies in the c3 and c4 complements (associated with lupus). I am negative for all of the antibodies that typically point to Sjogrens or Lupus. My rheumatologist just gave me the diagnosis of Undifferentiated Connective Tissue Disease (which from what I understand means she doesn't know what is going on but it could turn into something specific in the future). She is most concerned about the low complements. She was not particularly concerned about the ACA which surprised me. I find that very scary from what I've read! She says that the Lichen Planus is unrelated and says it should just be treated with steroid creams. But Lichen Planus is also an autoimmune disease from what I understand. I am going to re-run my blood work in early Jan and then see her again to consider whether or not I should go on Plaquenil. She said it might help with the fatigue and possibly prevent some problems in the future. At this point I am feeling very lucky that I am not feeling too bad but at the same time I am scared about what the future holds. I have 4 young kids and I'm worried how this might impact them. I know that no one can diagnose me over the internet but if anyone has any insights or suggestions on what I should ask my doctor, or perhaps additional tests I should ask for, I would be very grateful. Thank you so very much!
Undifferentiated connective tissue disease (UCTD), fibromyalgia and the environmental factors. Environmental factors are gaining increasing attention since the description of Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA), a syndrome that includes symptoms typically seen in patients with fibromyalgia and UCTD. PubMed, Curr Opin Rheumatol, 03/31/2017. (Also see Fibromyalgia and Undifferentiated Connective Tissue Disease) This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.