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Jeannie McClelland

Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma (SSc) vasculopathy

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Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma (SSc) vasculopathy. Friend leukemia integration factor 1 (Fli1), an important regulator of immune function and collagen fibrillogenesis, is expressed at reduced levels in endothelial cells in affected skin of patients with SSc. We show that Fli1 regulates expression of genes involved in maintaining vascular homeostasis including VE-cadherin, platelet endothelial cell adhesion molecule 1, type IV collagen, matrix metalloproteinase 9, platelet-derived growth factor B, and S1P(1) receptor. Y Asano.(PubMed) Am J Pathol. 2010 Apr;176(4):1983-98. (Also see: Endothelin and SSc and Skin Fibrosis)

 

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Jeannie McClelland

(Retired) ISN Director of Support Services

(Retired) ISN Sclero Forums Manager

(Retired) ISN Blog Manager

(Retired) ISN Assistant News Guide

(Retired) ISN Artist

International Scleroderma Network

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