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Researchers Point to Possible Scleroderma-Cancer Link

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Researchers Point to Possible Scleroderma-Cancer Link.


Patients with a certain type of scleroderma may get cancer and scleroderma simultaneously, Johns Hopkins researchers have found, suggesting that in some diseases, autoimmunity and cancer may be linked. Those with antibodies called anti-RNA polymerase I/III had the most closely related onset of cancer and scleroderma. EurekAlert! 06/08/10. (Also see: Scleroderma and Cancer and Antibodies)


This item was posted in the ISN Newsroom. Check the Newsroom every day for the latest scleroderma medical and support information.

Janey Willis

ISN Support Specialist

(Retired) ISN Assistant Webmaster

(Retired) ISN News Director

(Retired) ISN Technical Writer for Training Manuals

International Scleroderma Network (ISN)

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Hi Janey ,


Thanks for the article. Gareth has the + Anti-RNA Polymerase and it has risen slowly from 23 to 83 on his last draw (his 3rd testing for it). I wish there was a site that told of the significance of the numbers but I have yet to find it. I will bring this up to his new Rheumatologist when Gareth sees him for the first time.


Take care, Everyone.


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Hi Margaret,


If you look at the Antibodies link (go to the RNA section) Janey gave you, this article gives some information on levels.


A longitudinal study of anti-RNA polymerase III antibody (ARA) levels in systemic sclerosis. The pathogenic significance of ARA is unclear. Despite the very strong association of ARA with scleroderma renal crisis, we could not show the clinically significant association between absolute levels of antibody and development of internal organ complications, which makes repeated measurements of ARA levels unnecessary. However, changes in ARA level over time occur and may reflect changes in skin score. Svetlana I. Nihtyanova. Rheumatology. August 20, 2009.


It's frustrating when we get tested and have positive results, but no one really seems to be able to say what the significance is. Even finding out a 'normal' range can be frustrating. :rolleyes:


Warm hugs to you and Gareth,

Jeannie McClelland

(Retired) ISN Director of Support Services

(Retired) ISN Sclero Forums Manager

(Retired) ISN Blog Manager

(Retired) ISN Assistant News Guide

(Retired) ISN Artist

International Scleroderma Network

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