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Hi all


I have not visited the site for a little while as I have needed to hide the old head under the duvet for a bit.

I cannot seem to quite grasp the whole ANA and RNA subject in spite of looking at links. I think I am just a bit fuddled.I am also finding it difficult to use the computer for any length of time as it really hurts my hands and seems to make them quickly become swollen. Annoying because I have invested in an ergonomic mouse and even that isnt helping a lot.


Can you please explain my results

ANA +ve >1:100 fine speckled

RNA polymerase +ve



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Hi Vanessa,


Welcome back!


Oh, boy, ANA and RNA. Well, I'll have a go.


ANA +ve >1:100 fine speckled The +ve just means the test was positive. A negative would have been abbreviated as -ve. ANA is an anti-nuclear antibody and when you have a positive result, it will indicate the possibility of an autoimmune disease. The individual visual pattern of the antibodies seems to be somewhat specific to various types of autoimmune diseases:


  • Homogenous (diffuse) - associated with SLE (lupus) and mixed connective tissue disease
  • Speckled - associated with SLE, Sjogren's, scleroderma, polymyositis, rheumatoid arthritis, and mixed connective tissue disease
  • Nucleolar - associated with scleroderma and polymyositis
  • Outline pattern (peripheral) -associated with SLE

The 1:100 is the titer, or at what dilution the antibodies are still detectable. The first number is the antibody and the second number is the dilution. So 100 would be better than 1320, for instance.


RNA polymerase +ve RNA polymerase is an enzyme that enables the production of RNA (ribonucleic acid) from DNA and it is my understanding that this RNA transcribes and translates the genetic coding of the DNA to produce specific amino acids (proteins) which in turn enable the genes to produce what they are coded to do. IgG Anti-RNA Polymerase III is a predictive marker for systemic sclerosis (scleroderma).


So what I think might be going on is that perhaps you have symptoms of an autoimmune disease and your doctor is perhaps trying to pin down more exactly which one.


Hope this helps!

Jeannie McClelland

(Retired) ISN Director of Support Services

(Retired) ISN Sclero Forums Manager

(Retired) ISN Blog Manager

(Retired) ISN Assistant News Guide

(Retired) ISN Artist

International Scleroderma Network

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Hi Vanessa,


Like you, I've not been on the site for many weeks. I've had to slow down as I've got an intestinal hernia needing a small operation, and its painful to drive etc. I don't understand the test results much, but I hope your hands improve soon as its no fun, as we need our hands for everything don't we!


Take care,



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Hi Vanessa and Debs,


I'd just like to say "Welcome Back!" to both of you. It's the dog days of summer, and you are just leading the pack of folks who return to the forum after their summer break.


Vanessa, please bear in mind that your symptoms are more important than your antibodies, because some people who are perfectly healthy have wacky antibodies and some people who are severely ill have normal antibodies. Plus, there is no treatment for antibodies but there are treatments for the majority of symptoms. So, sometimes the antibody info is helpful and sometimes it's not, depending on our symptoms. Therefore, to me, your hurting and swollen hands are even more important than your antibodies, and I do hope that you have asked for a referral to an occupational therapist to learn techniques for maintaining all your hand function. There are many of us who are very grateful that we sought out occupational therapy for our hands at the very first sign of trouble!


Debs, I hope you are feeling better soon. Have you had surgery already, or are you about to have it?

Warm Hugs,


Shelley Ensz

Founder and President

International Scleroderma Network (ISN)

Hotline and Donations: 1-800-564-7099


The most important thing in the world to know about scleroderma is sclero.org.

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Thanks, Shelly

I am due to have the surgery next month, so I have to take it easy for a while. I can't pick up my lovely grandchildren, but they sure know how to scramble onto my lap! :VeryHappy:

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Thanks Jeannie and Shelley for the feedback.

I do loads of exercises for my hands, face and pilates and stretches for the rest of my bod. I am sure all that really helps.

Sorry to hear about the hernia Debs and best of luck with the op next month.

Just glimpsed a bit of sunshine. Delightful. Mind you its getting too nippy now. Plays havoc with the Raynaud's.

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