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Jeannie McClelland

Lung tissues in systemic sclerosis (SSc) have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension

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Lung tissues in systemic sclerosis (SSc) have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension Using microarray analysis on carefully phenotyped SSc and comparator lung tissues, we demonstrated distinct molecular profiles in tissues and fibroblasts of patients with SSc-associated lung disease compared to idiopathic forms of lung disease. Unique molecular signatures were generated that are disease- (SSc) and phenotype- (PF vs PAH) specific. Eileen Hsu (PubMed) Arthritis and Rheumatism, Nov. 19, 2010. (Also see: Genetics and Pulmonary Involvement)

 

This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.


Jeannie McClelland

(Retired) ISN Director of Support Services

(Retired) ISN Sclero Forums Manager

(Retired) ISN Blog Manager

(Retired) ISN Assistant News Guide

(Retired) ISN Artist

International Scleroderma Network

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Thanks for posting this, Jeannie.

 

I found it very interesting as I remember being very impressed when I first saw my consultant at The Royal Brompton Hospital. They were able to tell from the pattern of the 'ground glass' on my lungs that it was a fibrosing organising pneumonia caused by Scleroderma and not Idiopathic Pulmonary Fibrosis which was what I had convinced myself I was suffering from (having foolishly googled 'Pulmonary Fibrosis' and scared myself witless!! :rolleyes: )

 

My consultant was able to look me squarely in the eye and assure me I didn't have IPF....what a relief!! :emoticons-yes:


Jo Frowde

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