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Sex Differences in autoimmune disease

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Sex Differences in autoimmune disease.


Being female confers a greater risk of developing these diseases than any single genetic or environmental risk factor discovered to date. Understanding why would lead to an insight into the major pathways of disease pathogenesis and, secondly, it would likely lead to novel treatments which would disrupt such pathways. Rhonda Voskuhi. 7th Space Interactive. 01/04/11. (Also see: Causes of Scleroderma)


This item was posted in the ISN Newsroom. Please check the newsroom daily for updates on scleroderma and other related articles.

Janey Willis

ISN Support Specialist

(Retired) ISN Assistant Webmaster

(Retired) ISN News Director

(Retired) ISN Technical Writer for Training Manuals

International Scleroderma Network (ISN)

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Please correct me if I'm wrong, but I have read that although females are more likely to get scleroderma, males tend to have worse disease progression. Has anyone else heard this?



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Hi Colin,


That's an interesting question and I've included a link here to a report from The EULAR Scleroderma Trials and Research Group (EUSTAR) Database, which I hope you'll find informative.


How nice to hear from you again; we spoke in the chat room a few weeks ago and I do hope that the sclerodactyly of your fingers is not paining you too much and you are feeling better. :)

Jo Frowde

ISN Assistant Webmaster

SD World Webmaster

ISN Sclero Forums Manager

ISN News Manager

ISN Hotline Support Specialist

ISN Chat Host

International Scleroderma Network (ISN)

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Hi Colin ,


I see you're new to the site....welcome.


It will be 5 years, this Nov, that my son, age 18 at the time, was diagnosed with sine Scleroderma based on + ANA (speckled pattern,diffuse) + AntiRNA Polymerase 1/111, esophgeal dismotility, restrictive lung issues, chostocondritis, hardening of the vocal cords, 20# wt loss, and major fatigue. Needless to say, his senior year in HS was a blur. Because he only had the esoph. dismotility, no skin issues, and none of the other CREST symptoms, the doctors were at a loss as to what to do with him!!! Fortunately, they did start him on Plaquenil 9 months after the initial symptoms started and he is doing fairly well today. The esophagus loosened up and he only has dismotility in the lower 1/3 part but it doesn't seem to bother him much. They eventually gave him the diagnosis of UCTD, not sine Scleroderma. Last winter, he did develope Raynaud's but it isn't too bad and I rarely saw color changes this winter. He has also developed dry eyes and dry mouth (SICCA)but that can be from medications or Sjogren's. Funny but the med for Sjogren's is Plaquenil and he's been on it for 4 years now.


I understand the fear you may be feeling --- I thought I would lose my son at an early age, but this site is so full of compationate, understanding, and educational people that I soon realized much of what was out there in cyber space was wrong or outdated.


I would have to add that the biggest problem *I* had, as his Mom, was when they diagnosed him with autoimmune induced depression on top of all the other symptoms. Please, keep this in mind because the doctors told me that the same autoimmune responses fighting the body also can affect the chemicals of the brain.


Keep posting, keep asking questions, and keep a positive outlook on life.


Take care, Everyone.


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